Synthesis, spectral and thermal studies of the sodium salts of some Ru(III) complexes with quinolone antibiotics

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• 作者：Mihaela Badea ; Rodica Olar ; Luigi Silvestro…
• 关键词：Quinolone derivative ; Ruthenium(III) complex ; Sodium salt ; Thermal stability
• 刊名：Journal of Thermal Analysis and Calorimetry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：127
• 期：1
• 页码：721-729
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Physical Chemistry; Analytical Chemistry; Polymer Sciences; Inorganic Chemistry; Measurement Science and Instrumentation;
• 出版者：Springer Netherlands
• ISSN：1588-2926
• 卷排序：127

文摘

Solubilisation by salt formation is an effective method to increase the solubility of slightly soluble drugs, applied especially for the development of liquid formulations for parenteral administration. In the present study, this strategy is applied for new Ru(III) complexes with quinolone antibiotics, valuable for biological application such as anticancer activity. The parent compounds, formulated as RuCl₃(HL)₂(DMSO)_m(H₂O)_n (HL: pipemidic acid, norfloxacin, ciprofloxacin, ofloxacin, levofloxacin, enrofloxacin, enoxacin), were transformed in their corresponding soluble sodium salts with general formula Na₂RuCl₃(L)₂(DMSO)_m(EtOH)_n(H₂O)_p. The sodium salts have been characterised by elemental analysis and some spectrometric methods (IR, UV–Vis, mass spectra). The thermal behaviour of these newly compounds was studied by simultaneous TG/DTG/DTA analysis, and it was evidenced a higher thermal stability compared to that of the parent compounds. The thermal transformations occur in two or three steps and comprise solvent (solvation or coordination) elimination as well as oxidative degradation of quinolone derivatives. A mixture of ruthenium and sodium chloride was identified as final residue.