Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus

详细信息    查看全文

• 作者：I A Parshikov ; J P Freeman ; J O Lay Jr ; J D Moody ; A J Williams ; R D Beger and J B Sutherland
• 关键词：Keywords ; biotransformation ; fluoroquinolones ; Mucor ramannianus ; sarafloxacin
• 刊名：Journal of Industrial Microbiology and Biotechnology
• 出版年：2001
• 出版时间：March 2001
• 年：2001
• 卷：26
• 期：3
• 页码：140-144
• 全文大小：118 KB

文摘

To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26 % and 15 % of the A ₂₈₀, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed. Journal of Industrial Microbiology & Biotechnology (2001) 26, 140–144.