Spectrofluorimetric study and determination of desipramine in the presence of β-cyclodextrin

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• 作者：Fahimeh Jalali (1)
  Negin Ezzati (1)
  
• 关键词：desipramine ; spectrofluorimetry ; β ; cyclodextrin ; fluorescence enhancement
• 刊名：Journal of Analytical Chemistry
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：69
• 期：4
• 页码：367-370
• 全文大小：230 KB
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• 作者单位：Fahimeh Jalali (1)
  Negin Ezzati (1)
  
  1. Department of Chemistry, Razi Universit, 67346, Kermanshah, Iran
  
• ISSN：1608-3199

文摘

The native fluorescence intensity of desipramine was enhanced in the presence of β-cyclodextrin in aqueous solution. The inclusion complex formation between these compounds was studied by spectrofluorimetry. A stable complex with a 2: 1 stoichiometry of β-cyclodextrin to desipramine was formed (logβ2 = 9.29 ± 0.01). In the presence of an optimum concentration of β-cyclodextrin, the fluorescence intensity was linearly proportional to desipramine concentration in the range of 0.1-00 μg/mL (7.2 × 10??.0 × 10? M) with a limit of detection of 7 × 10? M. The method was successfully applied to the detection of desipramine in its tablets.