Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration

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• 作者：M. Julia García-Fuster ; Jesús A. García-Sevilla
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：233
• 期：15-16
• 页码：2955-2971
• 全文大小：2,643 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072
• 卷排序：233

文摘

RationaleFas-associated death domain (FADD) is an adaptor of death receptors that can also induce anti-apoptotic actions through its phosphorylated form (p-FADD). Activation of monoamine receptors, indirect targets of classic anti-depressant drugs (ADs), reduced FADD and increased p-FADD and p-FADD/FADD ratio in brain.