The Pattern of Elastic Fiber Breakdown in Bleomycin-Induced Pulmonary Fibrosis May Reflect Microarchitectural Changes
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- 作者：Xingjian Liu ; Shuren Ma ; Gerard Turino ; Jerome Cantor
- 关键词：COPD ; Emphysema ; Desmosine ; Elastin ; Percolation
- 刊名：Lung
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：195
- 期：1
- 页码：93-99
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Pneumology/Respiratory System;
- 出版者：Springer US
- ISSN：1432-1750
- 卷排序：195
文摘
IntroductionDesmosine and isodesmosine (DID) are unique elastin crosslinks that may serve as biomarkers for elastic fiber degradation in chronic obstructive pulmonary disease. Previously, our laboratory found that the ratio of free to peptide-bound DID in bronchoalveolar lavage fluid (BALF) showed a significant positive correlation with the extent of airspace enlargement in an elastase model of pulmonary emphysema. To further evaluate this hypothesis, our laboratory measured this ratio in a bleomycin (BLM) model of pulmonary fibrosis, which involved different microarchitectural changes than those associated with pulmonary emphysema.