In vitro tegumental alterations on adult Fasciola gigantica caused by mefloquine

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• 作者：Hatem A. Shalaby ; Amira H. El Namaky ; Reem O. A. Kamel
• 关键词：Fasciola gigantica ; Mefloquine ; Morphological changes ; Body wall
• 刊名：Journal of Parasitic Diseases
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：40
• 期：1
• 页码：145-151
• 全文大小：1,921 KB
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• 作者单位：Hatem A. Shalaby (1)
  Amira H. El Namaky (1)
  Reem O. A. Kamel (2)
  
  1. Department of Parasitology and Animal Diseases, National Research Center, Giza, Egypt
  2. Department of Zoology, Girls College for Art, Science and Education, Ain Shams University, Cairo, Egypt
  
• 刊物主题：Infectious Diseases; Health Promotion and Disease Prevention; Medicine/Public Health, general;
• 出版者：Springer India
• ISSN：0975-0703

文摘

Emergence of drug-resistant Fasciola strains has drawn the attention of many authors to alternative drugs. The purpose of this study is to explore the in vitro effect of the antimalarial mefloquine against adult Fasciola gigantica. Light and scanning electron microscopic observations could be used to determine the target of the drug following 6 and 12 h of incubation in medium containing mefloquine at three different concentrations 10, 20 and 30 μg/mL, as morphological changes could be observed. These changes occurred in definite sequences in response to mefloquine, and were consisted of swelling, vacuolization that was later disrupted, leading to desquamation of the tegument, resulting in exposure and disruption of basal lamina and the dislodging of spines. It is concluded that mefloquine presented itself as a drug that might become important in trematode chemotherapy, with the tegument being an important drug target.