Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment

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• 作者：Takayuki Baba ; Toshiyuki Oshitari…
• 关键词：αB ; crystallin ; Rhegmatogenous retinal detachment ; Vitreous ; Apoptosis ; Neuroprotection
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：253
• 期：8
• 页码：1251-1254
• 全文大小：199 KB
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• 作者单位：Takayuki Baba (1)
  Toshiyuki Oshitari (1)
  Shuichi Yamamoto (1)
  
  1. Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-0856, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose Alpha-B crystallin (αB-crystallin) is a molecular chaperone, and one of the small heat shock proteins (sHSPs). αB-crystallin has been shown to have neuroprotective properties. The purpose of this study was to determine the level of αB-crystallin in eyes with a rhegmatogenous retinal detachment (RRD). Methods Vitreous samples were collected before vitrectomy from 32 eyes of 32 consecutive patients with RRD. The concentration of αB-crystallin was measured by enzyme-linked immunosorbent assay (ELISA). Vitreous samples were also collected before vitrectomy from 16 patients with an idiopathic macular hole and epiretinal membrane, and used as controls. Results The mean age was 56?years (range, 31-7?years) in the RRD cases and 66?years (range, 49-7?years) in the controls. The mean level of αB-crystallin was significantly higher in the RRD cases (36.7?±-7.4?ng/ml) than that in controls (8.5?±-2.2?ng/ml; P--.0028). Conclusions The increased level of αB-crystallin suggests that αB-crystallin may play a neuroprotective role by lessening retinal cell death after a retinal detachment.