Simple and Fast Determination of Acrylamide and Metabolites in Potato Chips and Grilled Asparagus by Liquid Chromatography Coupled to Mass Spectrometry
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- 作者：Alejandra Ferrer-Aguirre ; Roberto Romero-González…
- 关键词：Acrylamide ; Potato chips ; Asparagus ; Metabolites ; UHPLC–Orbitrap ; MS
- 刊名：Food Analytical Methods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：9
- 期：5
- 页码：1237-1245
- 全文大小：476 KB
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Roberto Romero-González (1)
José Luis Martínez Vidal (1)
Antonia Garrido Frenich (1)
1. Group “Analytical Chemistry of Contaminants,” Department of Chemistry and Physics (Analytical Chemistry Area), Research Centre for Agricultural and Food Biotechnology (BITAL), University of Almería, Agrifood Campus of International Excellence, ceiA3, Carretera de Sacramento s/n, E-04120, Almería, Spain - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Food Science
Chemistry
Microbiology
Analytical Chemistry - 出版者：Springer New York
- ISSN：1936-976X
文摘
The purpose of this study was to evaluate an analytical procedure for the determination of acrylamide in different starchy foods such as potato chips and grilled asparagus. The method is based on high-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry (HPLC-QqQ-MS/MS). A solid–liquid extraction procedure, using water as extraction solvent, has been developed followed by a cleanup procedure based on solid-phase extraction (SPE) or dispersive solid-phase extraction (d-SPE). Polymeric cartridges (Oasis HLB) and aluminum oxide (Al2O3) were used for potato and asparagus matrices, respectively. The optimized procedures were validated, and limits of detection and quantitation were 4 and 12 μg/kg for potato chips and 2 and 5 μg/kg for grilled asparagus, respectively. Recoveries were evaluated, and good values were obtained, ranging from 90 to 117 % for potato chips and from 90 to 116 % for grilled asparagus. The method was applied to real samples, and concentrations ranged from 105 to 860 μg/kg in potato chips, whereas higher values were detected in grilled asparagus (from 292 to 1469 μg/kg). Furthermore, single-stage Orbitrap high-resolution mass spectrometry has been used for the putative identification of acrylamide-N-acetyl-S-(2-carbamoylethyl)-l-cysteine (AAMA) in urine.