Early Life Exposure to Ractopamine Causes Endocrine-Disrupting Effects in Japanese Medaka (Oryzias latipes)

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• 作者：Liwei Sun ; Sisi Wang ; Xia Lin ; Hana Tan…
• 关键词：β ; Agonist ; Endocrine disruption ; Gene transcription ; Gender ; specificity ; Hypothalamic–pituitary–gonadal (HPG) axis
• 刊名：Bulletin of Environmental Contamination and Toxicology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：96
• 期：2
• 页码：150-155
• 全文大小：665 KB
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• 作者单位：Liwei Sun (1)
  Sisi Wang (1)
  Xia Lin (1)
  Hana Tan (1)
  Zhengwei Fu (1)
  
  1. College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032, People’s Republic of China
  
• 刊物主题：Pollution, general; Environmental Health; Ecotoxicology; Soil Science & Conservation; Environmental Chemistry; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution;
• 出版者：Springer US
• ISSN：1432-0800

文摘

β-Agonists, which are used as human pharmaceuticals or feed additives, have been detected in aquatic environments. β-Agonists have also been proposed for use in aquaculture. However, there are limited data available regarding the adverse effects of β-agonists in aquatic organisms. In this study, ractopamine was selected as the representative β-agonist, and medaka embryos were exposed at concentrations ranging from 5 to 625 μg/L for 44 days. In contrast to what has been found in mammals, ractopamine caused no growth response in medaka. However, the transcriptional changes of genes related to the hypothalamic–pituitary–gonadal (HPG) axis, especially in females, suggested that β-agonists may have the potential to disrupt the endocrine system. Moreover, genes involved in anti-oxidative activity or detoxification were affected in a gender-specific manner. These findings, particularly the effects on the endocrine system of fish, will advance our understanding of the ecotoxicity of β-agonists. Keywords β-Agonist Endocrine disruption Gene transcription Gender-specificity Hypothalamic–pituitary–gonadal (HPG) axis