Apical control of conidiation in Aspergillus nidulans

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• 作者：Elixabet Oiartzabal-Arano ; Elixabet Perez-de-Nanclares-Arregi…
• 关键词：Filamentous fungi ; Polar growth ; Asexual reproduction ; Conidiation ; Upstream developmental activation ; Central developmental pathway
• 刊名：Current Genetics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：62
• 期：2
• 页码：371-377
• 全文大小：903 KB
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• 作者单位：Elixabet Oiartzabal-Arano (1)
  Elixabet Perez-de-Nanclares-Arregi (1)
  Eduardo A. Espeso (2)
  Oier Etxebeste (1)
  
  1. Biochemistry II Laboratory, Department of Applied Chemistry, Faculty of Chemistry, University of The Basque Country (UPV/EHU), Manuel de Lardizabal, 3, 20018, San Sebastian, Spain
  2. Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

The infection cycle of filamentous fungi consists of two main stages: invasion (growth) and dispersion (development). After the deposition of a spore on a host, germination, polar extension and branching of vegetative cells called hyphae allow a fast and efficient invasion. Under suboptimal conditions, genetic reprogramming of hyphae results in the generation of asexual spores, allowing dissemination to new hosts and the beginning of a new infection cycle. In the model filamentous fungus Aspergillus nidulans, asexual development or conidiation is induced by the upstream developmental activation (UDA) pathway. UDA proteins transduce signals from the tip, the polarity site of hyphae, to nuclei, where developmental programs are transcriptionally activated. The present review summarizes the current knowledge on this tip-to-nucleus communication mechanism, emphasizing its dependence on hyphal polarity. Future approaches to the topic will also be suggested, as stimulating elements contributing to the understanding of how apical signals are coupled with the transcriptional control of development and pathogenesis in filamentous fungi.