Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells
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  • 作者:Dexiang Zhang (1)
    Yueqi Wang (1)
    Yuedi Dai (2)
    Jiwen Wang (1)
    Tao Suo (1)
    Hongtao Pan (1)
    Han Liu (1)
    Sheng Shen (1)
    Houbao Liu (1) (3)

    1. General Surgery Department
    ; Zhongshan Hospital ; General Surgery Institute ; Fudan University ; Shanghai ; 200032 ; China
    2. Department of Medical Oncology
    ; Cancer Hospital of Fudan University ; Minhang Branch ; Shanghai ; 200240 ; China
    3. Zhongshan Hospital
    ; Fudan University ; 180 Fenglin Rd ; Shanghai ; 200032 ; China
  • 关键词:HCC ; RIP140 ; Beta ; catenin ; Cell proliferation and migration
  • 刊名:Tumor Biology
  • 出版年:2015
  • 出版时间:March 2015
  • 年:2015
  • 卷:36
  • 期:3
  • 页码:2077-2085
  • 全文大小:2,790 KB
  • 参考文献:1. Siegel, R, Naishadham, D, Jemal, A (2013) Cancer statistics, 2013. CA Cancer J Clin 63: pp. 11-30 CrossRef
    2. Dwyer, JP, Hosking, P, Lubel, J (2014) Multiple liver lesions in a patient with positive hepatitis C serology and elevated AFP: is it HCC?. Gastroenterology 147: pp. e12-e13 CrossRef
    3. Cho, JY, Paik, YH, Sohn, W (2014) Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease. Gut 63: pp. 1943-1950 CrossRef
    4. Levi, D, Tzakis, A (2009) HBV and HCC: comment on 鈥淩ole of hepatitis B virus infection in the prognosis after hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a Western dual-center experience鈥? Arch Surg 144: pp. 913 CrossRef
    5. Enwonwu, CO (1984) The role of dietary aflatoxin in the genesis of hepatocellular cancer in developing countries. Lancet 2: pp. 956-958 CrossRef
    6. Trevisani, F, Cantarini, MC, Labate, AM (2004) Surveillance for hepatocellular carcinoma in elderly Italian patients with cirrhosis: effects on cancer staging and patient survival. Am J Gastroenterol 99: pp. 1470-1476 CrossRef
    7. Park, EK, Kim, HJ, Kim, CY (2012) A comparison between surgical resection and radiofrequency ablation in the treatment of hepatocellular carcinoma. Ann Surg Treat Res 87: pp. 72-80 CrossRef
    8. Yamashita, Y, Imai, D, Bekki, Y (2012) Surgical outcomes of anatomical resection for solitary recurrent hepatocellular carcinoma. Anticancer Res 34: pp. 4421-4426
    9. Wan HG, Xu H, Gu YM, Wang H, Xu W, Zu MH (2014) Comparison osteopontin vs AFP for the diagnosis of HCC: a meta-analysis. Clin Res Hepatol Gastroenterol.
    10. Rienzo, G, Bishop, JA, Mao, Y (2012) Disc1 regulates both beta-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. Faseb J 25: pp. 4184-4197 CrossRef
    11. Kolligs, FT, Bommer, G, Goke, B (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66: pp. 131-144 CrossRef
    12. Cong, F, Schweizer, L, Varmus, H (2004) Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131: pp. 5103-5115 CrossRef
    13. Li, YJ, Wei, ZM, Meng, YX, Ji, XR (2005) Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis. World J Gastroenterol 11: pp. 2117-2123 CrossRef
    14. Stemmer, V, Craene, B, Berx, G, Behrens, J (2008) Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene 27: pp. 5075-5080 CrossRef
    15. Dahmani, R, Just, PA, Perret, C (2009) The Wnt/beta-catenin pathway as a therapeutic target in human hepatocellular carcinoma. Clin Res Hepatol Gastroenterol 35: pp. 709-713 CrossRef
    16. Cavard, C, Colnot, S, Audard, V (2008) Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology. Future Oncol 4: pp. 647-660 CrossRef
    17. Li, P, Cao, Y, Li, Y, Zhou, L, Liu, X, Geng, M (2012) Expression of Wnt-5a and beta-catenin in primary hepatocellular carcinoma. Int J Clin Exp Pathol 7: pp. 3190-3195
    18. Lin, J, Ding, L, Jin, R (2009) Four and a half LIM domains 1 (FHL1) and receptor interacting protein of 140 kDa (RIP140) interact and cooperate in estrogen signaling. Int J Biochem Cell Biol 41: pp. 1613-1618 CrossRef
    19. Cavailles, V, Dauvois, S, L'Horset, F (1995) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. Embo J 14: pp. 3741-3751
    20. Docquier, A, Harmand, PO, Fritsch, S, Chanrion, M, Darbon, JM, Cavailles, V (2012) The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes. Clin Cancer Res 16: pp. 2959-2970 CrossRef
    21. Zschiedrich, I, Hardeland, U, Krones-Herzig, A (2008) Coactivator function of RIP140 for NFkappaB/RelA-dependent cytokine gene expression. Blood 112: pp. 264-276 CrossRef
    22. Heery, DM, Hoare, S, Hussain, S, Parker, MG, Sheppard, H (2001) Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors. J Biol Chem 276: pp. 6695-6702 CrossRef
    23. Carascossa, S, Gobinet, J, Georget, V (2006) Receptor-interacting protein 140 is a repressor of the androgen receptor activity. Mol Endocrinol 20: pp. 1506-1518 CrossRef
    24. Docquier, A, Augereau, P, Lapierre, M (2012) The RIP140 gene is a transcriptional target of E2F1. PLoS One 7: pp. e35839 CrossRef
    25. Rytinki, MM, Palvimo, JJ (2008) SUMOylation modulates the transcription repressor function of RIP140. J Biol Chem 283: pp. 11586-11595 CrossRef
    26. Ho, PC, Gupta, P, Tsui, YC, Ha, SG, Huq, M, Wei, LN (2008) Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation. Cell Signal 20: pp. 1911-1919 CrossRef
    27. Heim, KC, Gamsby, JJ, Hever, MP (2009) Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140. PLoS One 4: pp. e7639 CrossRef
    28. Puri, V, Virbasius, JV, Guilherme, A, Czech, MP (2008) RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf) 192: pp. 103-115 CrossRef
    29. Morganstein, DL, Christian, M, Turner, JJ, Parker, MG, White, R (2008) Conditionally immortalized white preadipocytes: a novel adipocyte model. J Lipid Res 49: pp. 679-685 CrossRef
    30. Puri, V, Chakladar, A, Virbasius, JV (2007) RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res 48: pp. 465-471 CrossRef
    31. Powelka, AM, Seth, A, Virbasius, JV (2006) Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest 116: pp. 125-136 CrossRef
    32. Xue, J, Zhao, H, Shang, G (2012) RIP140 is associated with subclinical inflammation in type 2 diabetic patients. Exp Clin Endocrinol Diabetes 121: pp. 37-42 CrossRef
    33. Berriel Diaz, M, Krones-Herzig, A, Metzger, D (2008) Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice. Hepatology 48: pp. 782-791 CrossRef
    34. Nautiyal, J, Steel, JH, Mane, MR (2012) The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development 140: pp. 1079-1089 CrossRef
    35. Heim, KC, White, KA, Deng, D (2007) Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. Mol Cancer 6: pp. 57 CrossRef
    36. Lapierre, M, Bonnet, S, Bascoul-Mollevi, C (2012) RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest 124: pp. 1899-1913 CrossRef
  • 刊物主题:Cancer Research;
  • 出版者:Springer Netherlands
  • ISSN:1423-0380
文摘
Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel diagnosis biomarkers and therapeutic targets. RIP140, a regulator of estrogen receptor, recently has been found to be involved in the tumorigenesis. However, its function in the progression of HCC remains poorly understood. Here, we found that the expression of RIP140 was downregulated in the HCC tissues. Moreover, overexpression of RIP140 in HCC cells inhibited cell proliferation and migration, while downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, RIP140 interacted with beta-catenin and negatively regulated beta-catenin/TCF signaling. Taken together, our study suggests the suppressive roles of RIP140 in the pathogenesis of HCC.

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