Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case–control study

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• 作者：Zhen Liu (1) (2)
  Xiaohong Li (1)
  Nana Li (2)
  Shengli Li (3)
  Kui Deng (1)
  Yuan Lin (4)
  Xinlin Chen (5)
  Fengzhi You (6)
  Jun Li (7)
  Dezhi Mu (8)
  Yanping Wang (1)
  Jun Zhu (1) (2)
  
• 关键词：Air pollution ; Congenital heart disease ; Pregnancy ; Reproductive health ; Housing ; Indoor air
• 刊名：Environmental Health
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：12
• 期：1
• 全文大小：197KB
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• 作者单位：Zhen Liu (1) (2)
  Xiaohong Li (1)
  Nana Li (2)
  Shengli Li (3)
  Kui Deng (1)
  Yuan Lin (4)
  Xinlin Chen (5)
  Fengzhi You (6)
  Jun Li (7)
  Dezhi Mu (8)
  Yanping Wang (1)
  Jun Zhu (1) (2)
  
  1. National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China
  2. Laboratory of Molecular Epidemiology for birth defect, West China Institute of Women and Children’s Health, Sichuan University, Chengdu, China
  3. Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, Affiliated to Southern Medical University, Shenzhen, China
  4. Department of Obstetrics & Gynecology, Fujian provincial Maternal and Child Healthcare Hospital, Fuzhou, China
  5. Department of Ultrasound, Hubei provincial Maternal and Child Healthcare Hospital, Wuhan, China
  6. Department of women sanitation, Henan provincial Maternal and Child Healthcare Hospital, Zhengzhou, China
  7. Department of Ultrasonic Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi’an, China
  8. Department of Pediatric, West China Second University Hospital, Sichuan University, Chengdu, China
  

文摘

Background Congenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source of indoor environmental pollution that is detrimental to health. A growing body of research suggests that maternal occupational exposure to renovation materials may be associated with an increased risk of giving birth to fetuses with CHD. However, the effect of indoor housing renovation exposure on CHD occurrence has not been reported. Methods A multi-hospital case–control study was designed to investigate the association between maternal periconceptional housing renovation exposure and the risk of CHD for offspring. In total, 346 cases and 408 controls were enrolled in this study from four hospitals in China. Exposure information was based on a questionnaire given to women during pregnancy. The association between housing renovation exposure and CHD occurrence was assessed by estimating odds ratios (OR) with logistic regression models adjusted for potential confounders. Results The risk for CHD in offspring was significantly associated with maternal exposure to housing renovations (AOR: 1.89, 95% CI: 1.29-2.77). There were similar risks for cardiac defects with or without extra-cardiac malformation (AOR of 2.65 and 1.76, respectively). Maternal housing renovation exposure may increase the fetus-risk of suffering from conotruncal defect or anomalous venous return. There were significant risks for cardiac defects if the pregnant woman moved into a new house within one month after decoration at either 3?months before pregnancy (AOR: 2.38, 95% CI: 1.03 to 5.48) or during first trimester (AOR: 4.00, 95% CI: 1.62 to 9.86). Conclusions Maternal exposure to housing renovations may have an increased risk of giving birth to fetuses with some selected types of CHD. This relationship was stronger for women who moved into a newly decorated house. However, considering the limited number of subjects and the problem of multiple exposures, more research is needed to clarify the effects seen here.