Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer

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• 作者：D. Cragun ; D. Bonner ; J. Kim ; M. R. Akbari…
• 关键词：BRCA testing ; Genetic counseling ; Hereditary breast cancer ; Cancer registry ; Disparities
• 刊名：Breast Cancer Research and Treatment
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：151
• 期：1
• 页码：169-176
• 全文大小：585 KB
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• 作者单位：D. Cragun (1)
  D. Bonner (1)
  J. Kim (1)
  M. R. Akbari (2)
  S. A. Narod (2)
  A. Gomez-Fuego (1)
  J. D. Garcia (1)
  S. T. Vadaparampil (3)
  Tuya Pal (1)
  
  1. Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive MRC-CANCONT, Tampa, FL, 33612, USA
  2. Women’s College Research Institute, Women’s College Hospital, University of Toronto, Toronto, Canada
  3. Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7217

文摘

Concerns about the potential for genomic advances to increase health disparities have been raised. Thus, it is important to assess referral and uptake of genetic counseling (GC) and testing in minority populations at high risk for hereditary breast and ovarian cancer (HBOC). Black women diagnosed with invasive breast cancer ≤age 50 in 2009-012 were recruited through the Florida State Cancer Registry 6-8?months following diagnosis and completed a baseline questionnaire. Summary statistics, Chi-square tests, and path modeling were conducted to examine which demographic and clinical variables were associated with referral and access to genetic services. Of the 440 participants, all met national criteria for GC, yet only 224 (51?%) were referred for or received GC and/or HBOC testing. Variables most strongly associated with healthcare provider referral for GC included having a college education (OR 2.1), diagnosis at or below age 45 (OR 2.0), and triple negative tumor receptor status (OR 1.7). The strongest association with receipt of GC and/or HBOC testing was healthcare provider referral (OR 7.9), followed by private health insurance at diagnosis (OR 2.8), and household income greater than $35,000 in the year prior to diagnosis (OR 2.0). Study findings suggest efforts are needed to improve genetic services access among a population-based sample of high-risk Black women. These results indicate that socioeconomic factors and physician referral patterns contribute to disparities in access to genetic services within this underserved minority population.