Individuals living in a malaria-endemic area of Cameroon do not have an acquired antibody response to Plasmodium falciparum histidine-rich protein 2
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- 作者：Diane Wallace Taylor ; Naveen Bobbili ; Vedbar S. Khadka…
- 关键词：Plasmodium falciparum ; Malaria ; Diagnosis ; Rapid diagnostic tests ; Histidine ; rich protein II ; HRP2 ; HRP ; II ; Antibodies
- 刊名：Malaria Journal
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1578KB
- 刊物主题：Parasitology; Tropical Medicine; Infectious Diseases; Entomology; Microbiology; Public Health;
- 出版者：BioMed Central
- ISSN：1475-2875
- 卷排序：16
文摘
BackgroundDiagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody response to HRP2 with respect to prevalence, class, subclass, affinity, and age distribution in Cameroonian children and adults residing in an area with high P. falciparum transmission.