Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome

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• 作者：Christian Barmeyer ; Michael Schumann…
• 关键词：Irritable bowel syndrome ; Wheat ; sensitivity ; Gluten ; free diet ; HLA ; DQ2 ; HLA ; DQ8
• 刊名：International Journal of Colorectal Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：1
• 页码：29-39
• 全文大小：642KB
• 刊物类别：Medicine
• 刊物主题：Surgery; Internal Medicine; Gastroenterology; Hepatology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1262
• 卷排序：32

文摘

PurposeIrritable bowel syndrome (IBS) is common but therapies are unsatisfactory. Food is often suspected as cause by patients, but diagnostic procedures, apart from allergy testing, are limited. Based on the hypothesis of non-celiac wheat sensitivity (WS) in a subgroup of IBS patients, we tested the long-term response to a gluten-free diet (GFD) and investigated HLA-DQ2 or -DQ8 expression as a diagnostic marker for WS in diarrhea-dominant (IBS-D) and mixed-type IBS (IBS-M).