1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum
详细信息 查看全文
- 作者：Javier Vargas-Medrano ; Jorge A. Sierra-Fonseca…
- 关键词：Ca2+ ; ATPase ; Sarcoplasmic reticulum ; Dichlorobenzene ; Phosphoenzyme
- 刊名：BMC Biochemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：819 KB
- 刊物主题：Biochemistry, general; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2091
文摘
Background 1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-occurring enzymatic systems, including the effects on Ca2+-ATPases, have been poorly studied. Therefore, we aimed to study the effect of 1,2-DCB on the Ca2+-ATPase from sarcoplasmic reticulum (SERCA), a critical regulator of intracellular Ca2+ concentration.