Patients with rest-tremor and scans with ipsilateral dopaminergic deficit

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• 作者：Maria Aguirregomozcorta (1)
  Maria Stamelou (1)
  Angelo Antonini (2)
  Petra Schwingenschuh (1)
  Liz Prvulovich (3)
  Mark J. Edwards (1)
  John C. Dickson (3)
  Kailash P. Bhatia (1)
  
• 关键词：Ipsilateral ; DaTSCAN ; Parkinson’s disease ; Rest ; tremor ; Asymmetry index
• 刊名：Journal of Neurology
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：260
• 期：4
• 页码：1132-1135
• 全文大小：670KB
• 参考文献：1. Bostan AC, Dum RP, Strick PL (2010) The basal ganglia communicate with the cerebellum. Proc Natl Acad Sci USA 107:8452-456 CrossRef
  2. Calvini P, Rodriguez G, Inguglia F, Mignone A, Guerra UP, Nobili F (2007) The basal ganglia matching tools package for striatal uptake semi-quantification: description and validation. Eur J Nucl Med Mol Imaging 34:1240-253 CrossRef
  3. Gerfen CR, Staines WA, Arbuthnott GW, Fibiger HC (1982) Crossed connections of the substantia nigra in the rat. J Comp Neurol 207:283-03 CrossRef
  4. Hazrati LN, Parent A (1991) Contralateral pallidothalamic and pallidotegmental projections in primates: an anterograde and retrograde labeling study. Brain Res 567:212-23 CrossRef
  5. Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012) Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain 135(Pt 11):3206-226
  6. Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Toni I (2011) Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Ann Neurol 69:269-81 CrossRef
  7. Ilinsky IA, Kultas-Ilinsky K, Rosina A, Haddy M (1987) Quantitative evaluation of crossed and uncrossed projections from basal ganglia and cerebellum to the cat thalamus. Neuroscience 21:207-27 CrossRef
  8. Isaias IU, Benti R, Cilia R, Canesi M, Marotta G, Gerundini P, Pezzoli G, Antonini A (2007) [123I]FP-CIT striatal binding in early Parkinson’s disease patients with tremor vs. akinetic-rigid onset. NeuroReport 18:1499-502 CrossRef
  9. Koch W, Radau PE, Hamann C, Tatsch K (2005) Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J Nucl Med 46:1109-118
  10. Lewis MM, Du G, Sen S, Kawaguchi A, Truong Y, Lee S, Mailman RB, Huang X (2011) Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson’s disease. Neuroscience 177:230-39 CrossRef
  11. Lin JJ, Chang DC (1997) Tremor caused by ipsilateral chronic subdural hematoma Case illustration. J Neurosurg 87:474 CrossRef
  12. Pirker W (2003) Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Mov Disord 18(Suppl 7):S43–S51 CrossRef
  13. Spiegel J, Hellwig D, Samnick S, Jost W, Mollers MO, Fassbender K, Kirsch CM, Dillmann U (2007) Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease. J Neural Transm 114:331-35 CrossRef
  
• 作者单位：Maria Aguirregomozcorta (1)
  Maria Stamelou (1)
  Angelo Antonini (2)
  Petra Schwingenschuh (1)
  Liz Prvulovich (3)
  Mark J. Edwards (1)
  John C. Dickson (3)
  Kailash P. Bhatia (1)
  
  1. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
  2. Department for Parkinson’s disease, IRCCS San Camillo, 30126, Venice, Italy
  3. The Institute of Nuclear Medicine, University College London Hospitals NHS FoundationTrust, London, UK
  
• ISSN：1432-1459

文摘

Dopamine transporter imaging is typically abnormal in Parkinson’s disease and shows reduced striatal uptake, which is typically greater contralateral to the clinically more affected side. However, tremor-dominant Parkinson’s disease patients may have significantly lower uptake in the striatum ipsilateral to the rest-tremor compared to akinetic-rigid PD patients, implying a possible role of an ipsilateral deficit in the generation of rest-tremor.We report here three patients with rest-tremor and the unexpected finding of an ipsilateral presynaptic dopaminergic deficit with normal uptake contralateral to the rest-tremor in dopamine transporter imaging. We divided them in two groups, with and without a corresponding structural lesion in brain imaging. These data may suggest a role of ipsilateral dopaminergic deficit in the generation of rest-tremor. An explanation of these findings could be damage of crossed dopaminergic fibres from the substantia nigra to thalamus, which can cause motor impairment ipsilateral to dopamine depletion experimentally. This is speculative but there is no doubt that these cases exist and we encourage others to report similar cases, as this may assist in the better understanding of the yet unknown pathophysiology of rest-tremor.