Overcoming tumor immune evasion with an unique arbovirus

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• 作者：Bruce Lyday (1)
  Tony Chen (1)
  Santosh Kesari (2) (3)
  Boris Minev (3) (4) (5)
  
  1. PrimeVax ; LLC ; Garden Grove ; USA
  2. Department of Neurosciences ; Translational Neuro-Oncology Laboratories ; UC San Diego ; La Jolla ; CA ; 92093 ; USA
  3. Moores UCSD Cancer Center ; UC San Diego ; La Jolla ; CA ; 92093 ; USA
  4. Division of Neurosurgery ; UC San Diego ; La Jolla ; CA ; 92093 ; USA
  5. Genelux Corporation ; San Diego Science Center ; San Diego ; CA ; 92109 ; USA
  
• 关键词：Death Receptors ; Dendritic cell ; Dengue fever ; Hyperthermia ; Immunotherapy ; Immune Evasion ; Spontaneous Regression ; Soluble TRAIL
• 刊名：Journal of Translational Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：13
• 期：1
• 全文大小：2,355 KB
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• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Combining dendritic cell vaccination with the adjuvant effect of a strain of dengue virus may be a way to overcome known tumor immune evasion mechanisms. Dengue is unique among viruses as primary infections carry lower mortality than the common cold, but secondary infections carry significant risk of hypovolemic shock. While current immuno-therapies rely on a single axis of attack, this approach combines physiological (hyperthermic reduction of tumor perfusion), immunological (activation of effector cells of the adaptive and innate immune system), and apoptosis-inducing pathways (sTRAIL) to destroy tumor cells. The premise of using multiple mechanisms of action in synergy with a decline in the ability of the tumor cells to employ resistance methods suggests the potential of this combination approach in cancer immunotherapy.