Pankreasorgantransplantation bei Typ-1-Diabetes-Patienten

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作者：Prof. Dr. R. Landgraf (1) C. Dieterle (2)
关键词：Diabetes mellitus ; Pankreastransplantation ; Insel(zell ; )Transplantation ; Diabetische Folgekomplikationen ; Patienten ; und Organüberleben ; Diabetes mellitus ; Pancreas transplantation ; Islet transplantation ; Diabetes complications ; Patient and transplant survival
刊名：Der Diabetologe
出版年：2010
出版时间：September 2010
年：2010
卷：6
期：6
页码：451-459
全文大小：582KB
参考文献：1. Ablorsu E, Ghazanfar A, Mehra S et al (2008) Outcome of pancreas transplantation in recipients older than 50 years: a single-centre experience. Transplantation 86:1511-514 b013e3181891cd6">CrossRef 2. Arbogast H, Malaise J, Illner WD et al (2005) Rejection after simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 20 (Suppl 2):ii11–ii17, ii62 CrossRef 3. Armenti VT, Constantinescu S, Moritz MJ, Davison JM (2008) Pregnancy after transplantation. Transplant Rev 22:223-40 CrossRef 4. Becker BN, Brazy PC, Becker YT et al (2000) Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease. Kidney Int 57:2129-135 CrossRef 5. Biesenbach G, K?nigsrainer A, Gross C, Margreiter R (2005) Progression of macrovascular diseases is reduced in type 1 diabetic patients after more than 5 years successful combined pancreas-kidney transplantation in comparison to kidney transplantation alone. Transpl Int 18:1054-060 CrossRef 6. Cheung AT, Perez RV, Chen PC (1999) Improvements in diabetic microangiopathy after successful simultaneous pancreas-kidney transplantation: a computer-assisted intravital microscopy study on the conjunctival microcirculation. Transplantation 68:927-32 CrossRef 7. Dieterle C, Brendel M, Seissler J et al (2006) Therapie des Diabetes mellitus. Internist 47:489-01 CrossRef 8. Dieterle CD, Arbogast H, Illner WD et al (2007) Metabolic follow-up after long-term pancreas graft survival. Eur J Endocrinol 156:603-10 CrossRef 9. Dieterle CD, Schmauss S, Arbogast H et al (2007) Pulmonary function in patients with type 1 diabetes before and after simultaneous pancreas and kidney transplantation. Transplantation 83:566-69 CrossRef 10. DSO (2008) http://www.dso.de/ 11. Eberl N, Piehlmeier W, Dachauer S et al (2005) Blood flow in the skin of type 1 diabetic patients before and after combined pancreas/kidney transplantation. Diabetes Metab Res Rev 21:525-32 CrossRef 12. Fioretto P, Steffes MW, Sutherland DE et al (1998) Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 339:69-5 CrossRef 13. Frystykm J, Ritzel RA, Maubach J et al (2008) Comparison of pancreas-transplanted type 1 diabetic patients with portal-venous versus systemic-venous graft drainage: impact on glucose regulatory hormones and the growth hormone/insulin-like growth factor-I axis. J Clin Endocrinol Metab 93:1758-766 CrossRef 14. Giannarelli R, Coppelli A, Sartini MS et al (2002) Early improvement of unstable diabetic retinopathy after solitary pancreas transplantation. Diabetes Care 25:2358-359 CrossRef 15. Gross CR, Limwattananon C, Matthees BJ (1998) Quality of life after pancreas transplantation: a review. Clin Transplant 12:351-61 16. Gruessner AC, Sutherland DE (2005) Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin Transplant 19:433-55 CrossRef 17. Gruessner RW, Sutherland DE, Gruessner AC (2005) Survival after pancreas transplantation. JAMA 293:675; author reply 675-76 CrossRef 18. Gruessner RW, Sutherland DE, Kandaswamy R et al (2008) Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus. Transplantation 85:42-7 CrossRef 19. Gruessner AC, Sutherland DER, Gruessner RWG (2010) Pancreas transplantation in the United States: a review. Curr Opin Organ Transplant 15:93-01 b013e32833552d2">CrossRef 20. Jürgensen JS, Ulrich C, H?rstrup JH et al (2008) Sexual dysfunction after simultaneous pancreas-kidney transplantation. Transplant Proc 40:927-30 CrossRef 21. Hughes TA, Gaber AO, Amiri HS et al (1995) Kidney-pancreas transplantation. The effect of portal versus systemic venous drainage of the pancreas on lipoprotein composition. Transplantation 60:1406-412 CrossRef 22. Koznarova R, Saudek F, Sosna T et al (2000) Beneficial effect of pancreas and kidney transplantation on advanced diabetic retinopathy. Cell Transplant 9:903-08 23. La Rocca E, Fiorina P, Carlo V di et al (2001) Cardiovascular outcomes after kidney-pancreas and kidney-alone transplantation. Kidney Int 60:1964-971 CrossRef 24. Landgraf R (1996) Impact of pancreas transplantation on diabetic secondary complications and quality of life. Diabetologia 39:1415-424 CrossRef 25. Larsen JL (2004) Pancreas transplantation: indications and consequences. Endocr Rev 25:919-46 CrossRef 26. Leichtman AB, Cohen D, Keith D et al (2008) Kidney and pancreas transplantation in the United States, 1997-006: The HRSA breakthrough collaboratives and the 58 DSA challenge. Am J Transplant 8:946-57 CrossRef 27. McCullough KP, Keith DS, Meyer KH et al (2009) Kidney and pancreas transplantation in the United States, 1998-007: access for patients with diabetes and end-stage renal disease. Am J Transplant 9:894-06 CrossRef 28. Mehnert H, Standl E, Usadel K-H, H?ring H-U (Hrsg) (2003) Diabetologie in Klinik und Praxis, 5. vollst?ndig überarbeitete und erweiterte Aufl. Thieme, Stuttgart New York 29. Morath C, Zeier M, Dohler B et al (2008) Metabolic control improves long-term renal allograft and patient survival in type 1 diabetes. J Am Soc Nephrol 19:1557-563 CrossRef 30. Müller-Felber W, Landgraf R, Scheuer R et al (1993) Diabetic neuropathy 3 years after successful pancreas and kidney transplantation. Diabetes 42:1482-486 betes.42.10.1482">CrossRef 31. Navarro X, Sutherland DE, Kennedy WR (1997) Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 42:727-36 CrossRef 32. Ojo AO, Meier-Kriesche HU, Hanson JA et al (2001) The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation 71:82-0 CrossRef 33. Piehlmeier W, Bullinger M, Kirchberger I et al (1996) Evaluation of the quality of life of patients with insulin-dependent diabetes mellitus before and after organ transplantation with the SF 36 health survey. Eur J Surg Oncol 162:933-40 34. Reddy KS, Stablein D, Taranto S et al (2003) Long-term survival following simultaneous kidney-pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure. Am J Kidney Dis 41:464-70 CrossRef 35. Scalea JR, Butler CC, Munivenkatappa RB et al (2008) Pancreas transplant alone as an independent risk factor for the development of renal failure: a retrospective study. Transplantation 86:1789-794 b013e3181913fbf">CrossRef 36. Scheider A, Meyer-Schwickerath E, Nusser J et al (1991) Diabetic retinopathy and pancreas transplantation: a 3-year follow-up. Diabetologia 34 (Suppl 1):S95–S99 CrossRef 37. Shah AK, Clatworthy MR, Watson CJ (2009) Diabetic cheiroarthropathy following simultaneous pancreas-kidney transplantation. Transplant Int 22:670-71 CrossRef 38. Sindhi R, Stratta RJ, Lowell JA et al (1997) Experience with enteric conversion after pancreatic transplantation with bladder drainage. J Am Coll Surg 184:281-89 39. Smets YF, Westendorp RG, Pijl JW van der et al (1999) Effect of simultaneous pancreas-kidney transplantation on mortality of patients with type-1 diabetes mellitus and end-stage renal failure. Lancet 353:1915-919 CrossRef 40. Sollinger HW, Odorico JS, Becker YT (2009) One thousand simultaneous pancreas-kidney transplants at a single center with 22-year follow-up. Ann Surg 250:618-30 41. Sureshkumar KK, Patel BM, Markatos A et al (2006) Quality of life after organ transplantation in type 1 diabetics with end-stage renal disease. Clin Transplant 20:19-5 CrossRef 42. Tyden G, Bolinder J, Solders G et al (1999) Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation. Transplantation 67:645-48 CrossRef 43. United States Renal Data System (USRDS), National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (2007) Annual Report. USRDS, Bethesda 44. Venstrom JM, McBride MA, Rother KI et al (2003) Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA 290:2817-823 CrossRef 45. Waki K, Terasaki PI (2006) Kidney graft and patient survival with and without a simultaneous pancreas utilizing contralateral kidneys from the same donor. Diabetes Care 29:1670-672 CrossRef 46. Weiss AS, Smits G, Wiseman AC (2009) Twelve-month pancreas graft function significantly influences survival following simultaneous pancreas-kidney transplantation. Clin J Am Soc Nephrol 4:988-95 CrossRef 47. White SA, Shaw JA, Sutherland DER (2009) Pancreas transplantation. Lancet 373:1808-817 CrossRef 48. Wolfe RA, McCullough KP, Schaubel DE et al (2008) Calculating Life Years from Transplant (LYFT): methods for kidney and kidney-pancreas candidates. Am J Transplant 8:997-011 CrossRef
作者单位：Prof. Dr. R. Landgraf (1) C. Dieterle (2) 1. Deutsche Diabetes-Stiftung, Staffelseestr. 6, 81477, München, Deutschland 2. ?rztehaus Harlaching, München, Deutschland

文摘

Pancreas grafting is mainly performed in combination with kidney transplantation in uremic type 1 diabetic patients. According to international statistics and studies, the 1-year/10-year survival rates after simultaneous kidney/pancreas transplantation are 94%-00%/79%, 89-2%/63% for kidneys and 85%-7%/53% for the pancreas. The high success rate with long-lasting normalization of glucose metabolism leads to an improvement in quality of life and to a stabilization and/or amelioration of secondary complications, as well as to a significant reduction in mortality, which is much higher compared to that of kidney graft recipients with a comparable risk profile. Pancreas transplantation alone in patients with good kidney function or after successful renal grafting (living-related donation) requires careful indication.

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