Sex and age differences in the expression of liver microRNAs during the life span of F344 rats

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• 作者：Joshua C. Kwekel ; Vikrant Vijay ; Tao Han ; Carrie L. Moland…
• 关键词：Sex difference ; Age difference ; Liver ; miRNA expression
• 刊名：Biology of Sex Differences
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：3223KB
• 刊物主题：Human Physiology; Endocrinology;
• 出版者：BioMed Central
• ISSN：2042-6410
• 卷排序：8

文摘

BackgroundPhysiological factors such as age and sex have been shown to be risk factors for adverse effects in the liver, including liver diseases and drug-induced liver injury. Previously, we have reported age- and sex-related significant differences in hepatic basal gene expression in rats during the life span that may be related to susceptibility to such adverse effects. However, the underlying mechanisms of the gene expression changes were not fully understood. In recent years, increasing evidence for epigenetic mechanisms of gene regulation has fueled interest in the role of microRNAs (miRNAs) in toxicogenomics and biomarker discovery. We therefore proposed that significant age and sex differences exist in baseline liver miRNA expression, and that comprehensive profiling of miRNAs will provide insights into the epigenetic regulation of gene expression in rat liver.