Skin-derived multipotent stromal cells -an archrival for mesenchymal stem cells

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• 作者：Radhakrishnan Vishnubalaji (12)
  May Al-Nbaheen (1) malnbaheen@ksu.edu.sa
  Balamuthu Kadalmani (2)
  Abdullah Aldahmash (13)
  Thiyagarajan Ramesh (4) thiyagaramesh@gmail.com
• 关键词：Stromal cell – Mesenchymal stem cell – Skin – Adherent cells – Floating spheres
• 刊名：Cell and Tissue Research
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：350
• 期：1
• 页码：1-12
• 全文大小：650.9 KB
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• 作者单位：1. Stem Cell Unit, Department of Anatomy, King Saud University, Riyadh, 11472 Kingdom of Saudi Arabia2. Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024 India3. KMEB, Department of Endocrinology, University of Southern Denmark, Odense, Denmark4. Department of Applied Biochemistry, Division of Life Science, College of Biomedical and Health Science, Konkuk University, Chungju, 380-701 Korea
• ISSN：1432-0878

文摘

Progenitor stem cells have been identified, isolated and characterized in numerous tissues and organs. However, their therapeutic potential and the use of these stem cells remain elusive except for a few progenitor cells from bone marrow, umbilical cord blood, eyes and dental pulp. The use of bone marrow-derived hematopoietic stem cells (HSC) or mesenchymal stem cells (MSCs) is restricted due to their extreme invasive procedures, low differentiation potential with age and rejection. Thus, we need a clinical grade alternative to progenitor stem cells with a high potential to differentiate, na?ve and is relatively easy in in vitro propagation. In this review, we summarize cell populations of adherent and floating spheres derived from different origins of skin, or correctly foreskin, by enzymatic digestion compared with established MSCs. The morphology, phenotype, differentiation capability and immunosuppressive property of the adherent cell populations are comparable with MSCs. Serum-free cultured floating spheres have limited mesodermal but higher neurogenic differentation potential, analogous to neural crest stem cells. Both the populations confirmed their plethora potential in in vitro. Together, it may be noted that the skin-derived adherent cell populations and floating cells can be good alternative sources of progenitor cells especially in cosmetic, plastic and sports regenerative medicine.