Evaluation of the effects of methanol leaf extract of Palisota hirsuta on the biochemical and hematological parameters of rats

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• 作者：Ihemdirim Chukwuma Unamba-Oparah ; C. Unamba-Oparah…
• 关键词：Sub ; acute toxicity ; Hematology ; Methanol extract ; Palisota hirsuta ; Serum biochemistry
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：25
• 期：2
• 页码：271-277
• 全文大小：800 KB
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• 作者单位：Ihemdirim Chukwuma Unamba-Oparah (3)
  C. Unamba-Oparah (2)
  A. O. Anaga (1)
  
  3. Department of Veterinary Pathology, University of Nigeria, Nsukka, Enugu State, Nigeria
  2. Department of Veterinary Surgery, University of Nigeria, Nsukka, Enugu State, Nigeria
  1. Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

The effects of 28-day oral administration of the methanol leaf extract of Palisota hirsuta (MLEPH) on biochemical, hematological parameters, and relative organ weights (ROWs) in albino rats were investigated. There were no significant (p > 0.05) variations in the ROW of the heart, kidney, spleen, and liver on days 14 and 28 in all the rats given the different doses of MLEPH. The hematology showed that there were no significant (p > 0.05) alterations of the packed cell volume (PCV), hemoglobin concentration, RBC count, total white blood cell (tWBC), and differential WBC counts by MLEPH at 20, 40, 80, and 160 mg/kg when compared with control. The serum biochemistry also revealed no significant (p > 0.05) variations in the serum activities of aspartate aminotransferase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), total protein, total bilirubin, and creatinine when the groups that received the extract at the different doses were compared with the control. Therefore, MLEPH did not cause significant toxicity after 28 days of oral administration.