An efficient synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one
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- 作者：Longjiang Huang ; Yuan Tian ; Dawei Teng
- 关键词：Azetidine ; Spiro[azetidin ; 2 ; 3′-quinolin] ; 2′-one ; Intramolecular alkylation
- 刊名：Research on Chemical Intermediates
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1
- 页码：219-228
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Catalysis; Physical Chemistry; Inorganic Chemistry;
- 出版者：Springer Netherlands
- ISSN：1568-5675
- 卷排序：43
文摘
A facile synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one is described. Synthetic highlights include simultaneous construction of azetidine ring by intramolecular alkylation and formation of spirocarbon center in excellent yield plus removal of p-methoxybenzyl (PMB) amide protective group in mild condition with good yield.