Magnesium retards the progress of the arterial calcifications in hemodialysis patients: a pilot study

详细信息    查看全文

• 作者：Ioannis P. Tzanakis (1) (5)
  Elisavet E. Stamataki (1) (5)
  Antonia N. Papadaki (1) (5)
  Nektarios Giannakis (2) (5)
  Nikolaos E. Damianakis (3) (5)
  Dimitrios G. Oreopoulos (4) (5)
  
• 关键词：Magnesium ; Arteries ; Calcifications ; Hemodialysis
• 刊名：International Urology and Nephrology
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：46
• 期：11
• 页码：2199-2205
• 全文大小：676 KB
• 参考文献：1. Foley RN, Parfrey PS (1998) Cardiovascular disease and mortality in ESRD. J Nephrol 11:239-45
  2. Speer MY, Giachelli CM (2004) Regulation of cardiovascular calcification. Cardiovasc Pathol 13:63-0 CrossRef
  3. Rayssiguier Y (1986) Magnesium, lipids and vascular diseases. Experimental evidence in animal models. Magnesium 5(3-):182-90
  4. Cohen H, Sherer Y, Shaish A, Shoenfeld Y, Levkovitz H, Bitzur R et al (2002) Atherogenesis inhibition induced by magnesium-chloride fortification of drinking water. Biol Trace Elem Res 90(1-):251-59 CrossRef
  5. Schwille PO, Schmiedl A, Schwille R, Brunner P, Kissler H, Cesnjevar R et al (2003) Media calcification, low erythrocyte magnesium, altered plasma magnesium, and calcium homeostasis following grafting of the thoracic aorta to the infrarenal aorta in the rat differential preventive effects of long-term oral magnesium supplementation alone and in combination with alkali. Biomed Pharmacother 57(2):88-7 CrossRef
  6. Kircelli F, Peter ME, Ok ES, Celenk FG, Yilmaz M, Steppan S et al (2012) Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner. Nephrol Dial Transplant 27:514-21 CrossRef
  7. Salem S, Bruck H, Bahlmann FH, Peter M, Passlick-Deetjen J, Kretschmer A et al (2012) Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification. Am J Nephrol 35(1):31-9 CrossRef
  8. Louvet L, Büchel J, Steppan S, Passlick-Deetjen J, Massy ZA (2013) Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells. Nephrol Dial Transplant 28:869-78 CrossRef
  9. Meema HE, Oreopoulos DG, Rapoport A (1987) Serum magnesium level and arterial calcification in end-stage renal disease. Kidney Int 32:388-94 CrossRef
  10. Tzanakis I, Pras A, Kounali D, Mamali V, Kartsonakis V, Mayopoulou-Symvoulidou D et al (1997) Mitral annular calcifications in haemodialysis patients: a possible protective role of magnesium. Nephrol Dial Transplant 12(9):2036-037 CrossRef
  11. Tzanakis I, Virvidakis K, Tsomi A, Mantakas E, Girousis N, Karefyllakis N et al (2004) Intra- and extracellular magnesium levels and atheromatosis in haemodialysis patients. Magnes Res 17(2):102-08
  12. Ishimura E, Okuno S, Kitatani K, Tsuchida T, Yamakawa T, Shioi A, Inaba M, Nishizawa Y (2007) Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients. Clin Nephrol 68(4):222-27 CrossRef
  13. Spiegel DM, Farmer B (2009) Long-term effects of magnesium carbonate on coronary artery calcification and bone mineral density in hemodialysis patients: a pilot study. Hemodial Int 13:453-59 CrossRef
  14. Ishimura E, Okuno S, Yamakawa T, Inaba M, Nishizawa Y (2007) Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients. Magnes Res 20(4):237-44
  15. Tzanakis I, Tsomi A, Mantakas E, Papadaki A, Kallivretakis N (2006) The higher intracellular magnesium, the better long-term survival on hemodialysis. Presented in ASN Congress (Renal Week) November 14-9 2006, San Diego, USA
  16. Lacson EK, Wang W, Lazarus M, Hakim R (2009) Magnesium and mortality risk in hemodialysis patients. Presented in ASN Congress (Renal Week), October 27–November 1, 2009, San Diego, USA
  17. Kanbay M, Yilmaz MI, Apetrii M, Saglam M, Yaman H, Unal HU et al (2012) Relationship between serum magnesium levels and cardiovascular events in chronic kidney disease patients. Am J Nephrol 36(3):228-37 CrossRef
  18. Adragao T, Pires A, Lucas C, Birne R, Magalhaes L, Gon?alves M et al (2004) A
• 作者单位：Ioannis P. Tzanakis (1) (5)
  Elisavet E. Stamataki (1) (5)
  Antonia N. Papadaki (1) (5)
  Nektarios Giannakis (2) (5)
  Nikolaos E. Damianakis (3) (5)
  Dimitrios G. Oreopoulos (4) (5)
  
  1. Department of Nephrology, Chania General Hospital, 18 Michali Mefa st, Chania, Crete, PC 73100, Greece
  5. Renal Unit, General Hospital of Chania, PC 73300, Mournies, Chania, Greece
  2. Department of Radiology, Chania General Hospital, Chania, Greece
  3. Chania General Hospital, Chania, Greece
  4. Department of Nephrology, Toronto Western Hospital, Toronto, ON, Canada
  
• ISSN：1573-2584

文摘

Background The aim of the study was to evaluate the impact of magnesium (Mg) on the evolution of arterial calcifications in hemodialysis patients. Patients and methods Seventy-two stable hemodialysis patients were randomly allocated to two groups: 36 administered a regimen containing magnesium carbonate plus calcium acetate as a phosphate binder (Mg group), while the rest 36 received calcium acetate alone (Ca group). The presence and the progression of arterial calcifications were evaluated in plain X-rays using a simple vascular calcification score. The duration of the follow-up period was 12?months. Results Thirty-two patients of the Mg group and 27 of the Ca group completed the study. The mean time average values of the biochemical laboratories did not differ between the two groups, except serum Mg: 2.83?+?0.38 in the Mg group versus 2.52?+?0.27?mg/dl in the Ca group, p?=?0.001. In 9/32 (28.12?%) patients of the Mg group and in 12/27 (44.44?%) patients of the Ca group, the arterial calcifications were worsened, p?=?0.276. Moreover, in 4/32 (15.6?%) patients of the Mg group and in 0/27 (0?%) patients of the Ca group, they were improved, p?=?0.040. The multivariate logistic regression analysis revealed that serum magnesium was an independent predictor for no progression of the arterial calcifications, p?=?0.047. Conclusions Magnesium probably retards the arterial calcifications in hemodialysis patients. Further clinical studies are needed to clarify whether magnesium provides cardiovascular protection to this group of patients.