Antibacterial activity of polymeric quaternary ammonium compounds tuned by incorporating hydrophilic co-monomer

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• 作者：Huajiang Zuo (1) (2)
  Wanhua Wen (1)
  Dingcai Wu (1)
  Ruowen Fu (1)
  Chunyi Tang (2)
  
  1. PCFM Laboratory ; School of Chemistry and Chemical Engineering ; Sun Yat-sen University ; Guangzhou ; 510275 ; P. R. China
  2. College of Biological and Chemical Engineering ; Guangxi University of Science and Technology ; Liuzhou ; 545006 ; P. R. China
  
• 关键词：Polymeric quaternary ammonium compound ; Antibacterial mechanism ; Copolymerization ; Hydrophobic/hydrophilic balance
• 刊名：Chemical Research in Chinese Universities
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：31
• 期：1
• 页码：160-166
• 全文大小：857 KB
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• 刊物主题：Chemistry/Food Science, general; Analytical Chemistry; Inorganic Chemistry; Organic Chemistry; Physical Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：2210-3171

文摘

Copolymers of quaternary ammonium monomer(QAM) and hydrophilic co-monomer were successfully synthesized by free radical polymerization. It was discovered that the hydrophilic co-monomers with poor antibacterial activity significantly enhanced the activity of QAM substituted with a long alkyl chain[i.e., N,N-dimethyl-N-dodecyl methacrylate ammonium bromide(DMAEMA-DB)]. When a suitable molar ratio of DMAEMA-DB to co-monomer was selected, the activity of the copolymers was up to 123 times that of the homopolymer of DMAEMA-DB against S. aureus, and 282 times that of it against E. coli. But unlike DMAEMA-DB, the co-monomers might weaken the activity of QAM substituted with a short alkyl chain[i.e., N,N-dimethyl-N-butyl methacrylate ammonium bromide(DMAEMA-BB)]. Moreover, it was found that copolymers of DMAEMA-DB were much more biocidal than those of DMAEMA-BB. Therefore, it could be speculated that the long alkyl chain plays an important role in the antibacterial activity, and that the hydrophilic co-monomers are beneficial to polymeric guaternary ammonium compounds(PQACs) to exert the positive effect of the long alkyl chain to the greatest degree.