Crystal structure and antitumor activities of a dinuclear cobalt(II) complex based on meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane
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- 作者：Q.-W. Huang ; S.-X. Wang ; S.-G. Liu ; W.-Y. Su ; G.-B. Li…
- 关键词：benzimidazole ; cobalt complex ; crystal structure ; antitumor activities
- 刊名：Journal of Structural Chemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：57
- 期：1
- 页码：188-193
- 全文大小：324 KB
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20.G. M. Sheldrick, SHELXL-97, Program for the Refinement of Crystal Structures, University of Göttingen, Germany, (1997). - 作者单位：Q.-W. Huang (1)
S.-X. Wang (2)
S.-G. Liu (1)
W.-Y. Su (1)
G.-B. Li (1)
Y.-M. He (1)
1. School of Chemistry and Chemical Engineering, Lingnan Normal University, Development Center for New Materials Engineering and Technology in Universities of Guangdong, Zhanjiang, P. R. China
2. Institute of Molecular Medicine, Medical School of Shenzhen University, Shenzhen, P. R. China - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Inorganic Chemistry
Physical Chemistry
Atoms, Molecules, Clusters and Plasmas
Atomic and Molecular Structure and Spectra
Solid State Physics and Spectroscopy
Russian Library of Science - 出版者：Springer New York
- ISSN：1573-8779
文摘
The [Co2(tbb)Cl4]∙4DMF complex, where tbb is meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane, is synthesized and characterized by single crystal X-ray diffraction. For the complex: C44H54Co2Cl4N12O4, M r = 1074.65, monoclinic crystal system, space group P21/n, a = 9.2350(13) Å, b = 11.3566(15) Å, c = 23.879(3) Å, β = 90.547(2)°, V = 2504.3(6) Å3, Z = 2, D c = 1.425 g/cm3, λ = 0.71073 Å, μ(MoK α ) = = 0.929 mm–1, F(000) = 1112, S = 1.047, R = 0.0765, and wR = 0.2110 for 13668 observed reflections with I > 2σ(I). It is a neutral dinuclear complex. One meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane coordinates two cobalt(II) ions. Each cobalt(II) ion is formed by two tbb nitrogen atoms and two chloride ions. The antiproliferative activities of the complex are screened by MTT assay against Eca109 cancer cells. The complex exhibits inhibition on the growth of Eca109 cancer cells with IC50 of 22.1±6.7 μM after 48 h treatment. The cobalt complex has potential application in treatment of Eca109 cancer. CCDC 1015791.