文摘
Pleth variability index (PVI), a noninvasive dynamic indicator of fluid responsiveness has been demonstrated to be useful in the management of the patients with goal directed fluid therapy under general anesthesia, but whether PVI can be used to optimize fluid management under combined general and epidural anesthesia (GEN–EPI) remains to be elucidated. The aim of our study was to explore the impact of PVI as a goal-directed fluid therapy parameter on the tissue perfusion for patients with GEN–EPI. Thirty ASA I–II patients scheduled for major abdominal surgeries under GEN–EPI were randomized into PVI-directed fluid management group (PVI group) and non PVI-directed fluid management group (control group). 2?mL/kg/h crystalloid fluid infusion was maintained in PVI group, once PVI?>?13?%, a 250?mL colloid or crystalloid was rapidly infused. 4-?mL/kg/h crystalloid fluid infusion was maintained in control group, and quick fluid infusion was initiated if mean arterial blood pressure (BP)?P?