A comparison of the histopathologic pattern of the left atrium in canine dilated cardiomyopathy and chronic mitral valve disease

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• 作者：Izabela Janus ; Agnieszka Noszczyk-Nowak ; Marcin Nowak…
• 关键词：Dilated cardiomyopathy ; Mitral valve disease ; Dog ; Left atrium ; Histopathology
• 刊名：BMC Veterinary Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：1
• 全文大小：1,086 KB
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• 作者单位：Izabela Janus (1)
  Agnieszka Noszczyk-Nowak (2)
  Marcin Nowak (1)
  Rafał Ciaputa (1)
  Małgorzata Kandefer-Gola (1)
  Urszula Pasławska (2)
  
  1. Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Wroclaw University of Environmental and Life Sciences, Wroclaw, 50375, Poland
  2. Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats Wroclaw University of Environmental and Life Sciences, Wroclaw, 50366, Poland
  
• 刊物主题：Veterinary Medicine; Zoology; Transgenics;
• 出版者：BioMed Central
• ISSN：1746-6148

文摘

Background Dilated cardiomyopathy (DCM) and chronic mitral valve disease (CMVD) in dogs are associated with heart chamber enlargement, also of the left atrium. DCM is often accompanied by rhythm disturbances (mainly atrial fibrillation or ventricular arrhythmias). In CMVD, arrhythmias are observed less frequently. It is still unclear whether left atrial enlargement in these diseases results from volume overload or if it is also connected with other factors (e.g. rhythm disturbances). This study was conducted on the left atrial myocardial specimens from 31 dogs, including those from 16 dogs with clinically diagnosed DCM and 15 dogs with CMVD. After fixation and staining (using haematoxylin-eosin and Masson-Goldner trichrome stain), the specimens underwent evaluation. Parenchymal changes (fibrosis, fatty infiltration, and vessel narrowing), degenerative changes (loss of striation, changes in cardiomyocyte structure, and abnormal cell nuclei) and the presence of inflammatory infiltrates were assessed.