Effect of ligustrazine injection on levels of interleukin-4 and interferon-γ in patients with bronchial asthma

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• 作者：Xiao-wen Che (1)
  Ying Zhang (1)
  Hui Wang (1)
  Wei Wang (1)
  
• 关键词：ligustrazine injection ; asthma ; lung function ; TH1/Th2 disequilibrium ; interleukin ; 4 ; interferon ; γ
• 刊名：Chinese Journal of Integrative Medicine
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：14
• 期：3
• 页码：217-220
• 全文大小：204KB
• 参考文献：1. Chen AG, Zhong NS. The development of diagnosis and treatment of bronchial asthma. Chin J Pract Intl Med (Chin) 1999;19(5):263-66.
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  7. LU GJ. Progress of IFN-r/ IL-4 imbalance in the development of bronchial asthma. J Pract Tradit Chin Intern Med (Chin) 2004;18(2):90-1.
  8. Yang L, Wang WJ, Li HL, et al. Effect of ligustrazine on the deposition of collagen in asthmatic rats. Jiangsu Med J (Chin) 2003;29(11):818-19.
  9. Yang L, Chen J, Wang WJ, et al. Effect of ligustrazine on Th1/Th2 imbalance in asthmatic rats. Jiangsu Med J (Chin) 2004;30(11):822-23.
  
• 作者单位：Xiao-wen Che (1)
  Ying Zhang (1)
  Hui Wang (1)
  Wei Wang (1)
  
  1. Department of Respiratory Medicine, Second Hospital of Shandong University, Jinan, 250033, China
  

文摘

Objective To explore the effect of ligustrazine injection (LI) on serum levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) in patients with bronchial asthma and determine the mechanism of action of LI in preventing and treating asthma. Methods Sixty-eight patients with mild or moderate bronchial asthma were assigned to two groups equally according to their sequence number, odd or even. The conventional treatment was administered to both groups, and LI was given to the treatment group by ultrasonic spray inhalation twice a day but not to the control group. The therapeutic course for all was 2 weeks. Further, 30 healthy subjects who had no history of smoking were enrolled as the normal control group. The clinical condition scores, frequency of attacks and dosage of Terbutaline inhaled were scored and recorded on the first day of hospitalization (before treatment) and after treatment. At the same time, the indexes of lung function, including forced expiratory volume in one second (FEV1), forced expiratory volume in one second to forced vital capacity ratio (FEV1%) and the peak expiratory flow (PEF) were determined before treatment. The levels of IL-4 and IFN-γ in peripheral blood were detected by ELISA before and after treatment, and compared with that of the healthy control group. Results After treatment, the clinical condition scores were found to be lower, indexes of lung function were elevated, but serum level of IL-4 and ratio of IL-4/IFN-γ were reduced in both groups, showing significant differences as compared to those before treatment (P<0.05). However, the changes in all the indexes were more significant in the treatment group than in the control group, also showing statistical significance (P<0.05). No significant difference was revealed when IFN-γ levels were compared before and after treatment in both groups, though a lowering trend could be seen, significant difference could not be found in the comparison of IFN-γ levels between groups after treatment (P>0.05). Conclusion LI shows good clinical effect in treating bronchial asthma, and its mechanism might be related to the suppression of the synthesis of IL-4, thus leading to the inhibition of TH2 cell subset preponderant response and immune equilibrium regulation.