The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation

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• 作者：Tomohiro Sakashita ; Akihiro Homma…
• 关键词：Maxillary sinus cancer ; Elective neck irradiation ; Intra ; arterial chemotherapy ; Radiotherapy ; Regional recurrence
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：271
• 期：10
• 页码：2767-2770
• 全文大小：169 KB
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• 作者单位：Tomohiro Sakashita (1)
  Akihiro Homma (1)
  Hiromitsu Hatakeyama (1)
  Satoshi Kano (1)
  Takatsugu Mizumachi (1)
  Jun Furusawa (1)
  Daisuke Yoshida (2)
  Noriyuki Fujima (2)
  Rikiya Onimaru (2)
  Kazuhiko Tsuchiya (2)
  Koichi Yasuda (2)
  Hiroki Shirato (2)
  Satoshi Fukuda (1)
  
  1. Department of Otolaryngology–Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan
  2. Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  
• ISSN：1434-4726

文摘

The efficacy of elective neck irradiation (ENI) for patients with N0 carcinoma of the maxillary sinus has been controversial. The purpose of our study was to investigate the incidence of late neck recurrence and the mortality rate from regional disease in patients with N0 maxillary sinus cancer after superselective cisplatin infusion and concomitant radiotherapy (RADPLAT) without ENI. We retrospectively analyzed 48 patients with N0 maxillary sinus cancer who underwent RADPLAT. Chemotherapy consisted of 100-20?mg/m2 superselective intra-arterial cisplatin administered at a median rate of four times weekly. Concurrent radiation therapy was administered at a median dose of 65?Gy without ENI. Late neck recurrence was observed in 8.3?% (4/48). Three patients underwent salvage neck dissection and survived without any evidence of disease. The remaining patient did not undergo neck dissection due to coexistence with distant metastasis, and he died of regional disease. The mortality rate from regional disease was calculated to be 2?% (1/48). The incidence of late neck recurrence was not frequent, and the mortality rate from regional disease was low. Salvage neck dissection was considered to be feasible for patients with late neck recurrence. When definitive radiotherapy and concomitant chemotherapy are applied, it is considered that ENI is not required for cases of N0 maxillary sinus cancer.