Is elective neck dissection indicated during salvage surgery for head and neck squamous cell carcinoma?

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• 作者：Alvaro Sanabria (1) (2)
  Carl E. Silver (4)
  Kerry D. Olsen (5)
  Jesus E. Medina (6)
  Marc Hamoir (7)
  Vinidh Paleri (8)
  Vanni Mondin (9)
  Alessandra Rinaldo (9)
  Juan P. Rodrigo (10) (11)
  Carlos Suárez (10) (11)
  Carsten C. Boedeker (12)
  Michael L. Hinni (13)
  Luiz P. Kowalski (14)
  Afshin Teymoortash (15)
  Jochen A. Werner (15)
  Robert P. Takes (16)
  Alfio Ferlito (17) (9)
  
• 关键词：Head and neck squamous cell carcinoma ; Neck dissection ; Chemoradiotherapy ; Surgery ; Salvage
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：271
• 期：12
• 页码：3111-3119
• 全文大小：239 KB
• 参考文献：1. Davies L, Welch HG (2006) Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg 135:451-57 CrossRef
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  3. Bataini JP (1993) Radiotherapy in N0 head and neck cancer patients. Eur Arch Otorhinolaryngol 250:442-45
  4. Comet B, Kramar A, Faivre-Pierret M, Dewas S, Coche-Dequeant B, Degardin M, Lefebvre JL, Lacornerie T, Lartigau EF (2012) Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study. Int J Radiat Oncol Biol Phys 84:203-09 CrossRef
  5. Heron DE, Rwigema JC, Gibson MK, Burton SA, Quinn AE, Ferris RL (2011) Concurrent cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: a single institution matched case-control study. Am J Clin Oncol 34:165-72
  6. Vermorken JB, Trigo J, Hitt R, Koralewski P, Diaz-Rubio E, Rolland F, Knecht R, Amellal N, Schueler A, Baselga J (2007) Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 25:2171-177 CrossRef
  7. Yao M, Roebuck JC, Holsinger FC, Myers JN (2005) Elective neck dissection during salvage laryngectomy. Am J Otolaryngol 26:388-92 CrossRef
  8. Dagan R, Morris CG, Kirwan JM, Werning JW, Vaysberg M, Amdur RJ, Mendenhall WM (2010) Elective neck dissection during salvage surgery for locally recurrent head and neck squamous cell carcinoma after radiotherapy with elective nodal irradiation. Laryngoscope 120:945-52
  9. Basheeth N, O’Leary G, Sheahan P (2013) Elective neck dissection for N0 neck during salvage total laryngectomy: findings, complications, and oncological outcome. JAMA OtolaryngolHead Neck Surg 139:790-96 CrossRef
  10. Yirmibesoglu E, Fried D, Shores C, Rosenman J, Weissler M, Hackman T, Chera BS (2013) Incidence of subclinical nodal disease at the time of salvage surgery for locally recurrent head and neck cancer initially treated with definitive radiation therapy. Am J Clin Oncol 36:475-80 CrossRef
  11. Tsang RK, Chung JC, Ng YW, To VS, Ho AC, Chan JY, Ho WK, Wei WI (2012) Efficacy of neck dissection for locoregional failures versus isolated nodal failures in nasopharyngeal carcinoma. Head Neck 34:638-42 CrossRef
  12. Lavertu P, Adelstein DJ, Saxton JP, Secic M, Wanamaker JR, Eliachar I, Wood BG, Strome M (1997) Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer. Head Neck 19:559-66 CrossRef
  13. Johansen LV, Grau C, Overgaard J (2004) Nodal control and surgical salvage after primary radiotherapy in 1782 patients with laryngeal and pharyngeal carcinoma. Acta Oncol 43:486-94
  14. Van der Putten L, de Bree R, Kuik DJ, Rietveld DH, Buter J, Eerenstein SE, Leemans CR (2011) Salvage laryngectomy: oncological and functional outcome. Oral Oncol 47:296-01 CrossRef
  15. Esteller E, Vega MC, López M, Quer M, León X (2011) Salvage surgery after locoregional failure in head and neck carcinoma patients treated with chemoradiotherapy. Eur Arch Otorhinolaryngol 268:295-01
  16. Sklenicka S, Gardiner S, Dierks EJ, Potter BE, Bell RB (2010) Survival analysis and risk factors for recurrence in oral squamous cell carcinoma: does surgical salvage affect outcome? J Oral Maxillofac Surg 68:1270-275
• 作者单位：Alvaro Sanabria (1) (2)
  Carl E. Silver (4)
  Kerry D. Olsen (5)
  Jesus E. Medina (6)
  Marc Hamoir (7)
  Vinidh Paleri (8)
  Vanni Mondin (9)
  Alessandra Rinaldo (9)
  Juan P. Rodrigo (10) (11)
  Carlos Suárez (10) (11)
  Carsten C. Boedeker (12)
  Michael L. Hinni (13)
  Luiz P. Kowalski (14)
  Afshin Teymoortash (15)
  Jochen A. Werner (15)
  Robert P. Takes (16)
  Alfio Ferlito (17) (9)
  
  1. Department of Surgery, Universidad de Antioquia, Hospital Pablo Tobón Uribe, Medellín, Colombia
  2. Department of Surgery, Universidad de La Sabana, Chia, Colombia
  4. Departments of Surgery and Otolaryngology, Head and Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
  5. Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN, USA
  6. Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma, OK, USA
  7. Department of Head and Neck Surgery, Head and Neck Oncology Program, St. Luc University Hospital and Cancer Center, Brussels, Belgium
  8. Department of Otolaryngology-Head and Neck Surgery, Newcastle upon Tyne Foundation Hospitals NHS Trust, Newcastle upon Tyne, UK
  9. ENT Clinic, University of Udine, Udine, Italy
  10. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain
  11. Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
  12. Department of Otorhinolaryngology-Head and Neck Surgery, Helios Hanseklinikum Stralsund, Stralsund, Germany
  13. Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Phoenix, AZ, USA
  14. Department Otorhinolaryngology-Head and Neck Surgery, Centro de Tratamento e Pesquisa Hospital do Cancer A.C. Camargo, S?o Paulo, Brazil
  15. Department of Otolaryngology-Head and Neck Surgery, Philipp University, Marburg, Germany
  16. Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
  17. ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy
  
• ISSN：1434-4726

文摘

Among patients with head and neck squamous cell carcinoma with a negative neck who are initially treated with (chemo)radiotherapy, a number of cases will recur locally without obvious neck recurrence. There is little information available as to the most efficacious management of the neck in these cases. We have reviewed the literature to see what conclusions can be drawn from previous reports. We conducted a bibliography search on MEDLINE and EMBASE databases. Studies published in the English language and those on squamous cell carcinoma of the oral cavity, nasopharynx, oropharynx, larynx and hypopharynx were included. Data related to neck management were extracted from the articles. Twelve studies satisfied the inclusion criteria. Five studies reported only one treatment plan (either neck dissection or observation), while the others compared neck dissection to observation. The rate of occult metastases ranged from 3.4 to 12?%. The studies included a variable distribution of primary sites and stages of the recurrent primary tumors. The risk of occult neck node metastasis in a clinically rN0 patient correlated with tumor site and T stage. Observation of the neck can be suggested for patients with T1-2 glottic tumors, who recurred with less advanced tumors (rT1-2). For patients with more advanced laryngeal recurrences or recurrence at other high-risk sites, neck dissection could be considered for the rN0 patient, particularly if the neck was not included in the previous radiation fields.