Haematologic effects of leukoreduction on canine whole blood post-filtration and post-storage

详细信息    查看全文

• 作者：Marcia Kikuyo Notomi ; Rafael Ruiz de Gopegui…
• 关键词：Dog ; Blood bank ; Transfusion ; Leukocytes ; Leukodepletion
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：25
• 期：1
• 页码：145-149
• 全文大小：252 KB
• 参考文献：Blasi B, D’Alessandro A, Ramundo N, Zolla L (2012) Red blood cell storage and cell morphology. Transfus Med 22:90–96. doi:10.​1111/​j.​1365-3148.​2012.​01139.​x PubMed CrossRef
  Bowden RA, Slichter SJ, Sayers M, Weisdorf D, Cays M, Schoch G, Banaji M, Haake R, Welk K, Fisher L, McCullough J, Miller W (1995) A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 86(9):3598–3603. doi:10.​1182/​blood-2002-10-3143 PubMed
  Brownlee L, Wardrop JK, Sellon RK, Meyers KM (2000) Use of prestorage leucoreduction filter effectively removes leukocytes from canine whole blood while preserving red blood cell viability. J Vet Intern Med 14:412–417. doi:10.​1111/​j.​1939-1676.​2000.​tb02249.​x PubMed CrossRef
  Bruil A, Beugeling T, Feijen J, van Aken WG (1995) The mechanisms of leukocyte removal by filtration. Transfus Med Rev 9(2):145–166. doi:10.​1016/​S0887-7963(05)80053-7 PubMed CrossRef
  Callan MB, Patel RT, Rux AH, Bandyopadhyay S, Sireci AN, O’Donnell PA, Ruane T, Sikora T, Marryott K, Sachais BS, Hod EA (2013) Transfusion of 28-day-old leucoreduced or non-leucoreduced stored red blood cells induces an inflammatory response in healthy dogs. Vox Sang 105(4):319–327. doi:10.​1111/​vox.​12058 PubMed PubMedCentral CrossRef
  Dzik S, Aubuchon J, Jeffries L, Kleinman S, Manno C, Murphy ME, Popovsky MA, Sayers M, Silberstein LE, Slichter SJ, Vamvakas EC (2000) Leukocyte reduction of blood components: public policy and new technology. Transfus Med Rev 114(1):34–52. doi:10.​1016/​S0887-7963(00)80114-5 CrossRef
  Ergül Ekiz E, Arslan M, Akyazi I, Eraslan Uygur E, Inal Gültekin G, Özcan M (2012) The effects of prestorage leukoreduction and storage duration on the in vitro quality of canine packed red blood cells. Turk J Vet Anim Sci 36(6):711–717. doi:10.​3906/​vet-1110-25
  Fresenius K (2014) Transfusion technology: BioR and BioP filters. Fresenius Kabi Product Catalogue. Oberursel, Germany
  Graf C, Raila J, Schweigert FJ, Kohn B (2012) Effect of leukoreduction treatment on vascular endothelial growth factor concentration in stored canine blood transfusion products. Am J Vet Res 73(12):2001–2006. doi:10.​2460/​ajvr.​73.​12.​2001 PubMed CrossRef
  Hohenhaus AE (2007) Transfusions containing red blood cells. Proceedings of the World Small Animal Veterinary Association WSAVA Congress, Sydney, Australia
  Karger R, Lukow C, Kretschmer V (2011) The influence of maintaining the correct whole blood-to-anticoagulant ratio during donation on the quality of leukoreduced whole blood. Transfusion 51:1486–1492. doi:10.​1111/​j.​1537-2995.​2010.​03030.​x PubMed CrossRef
  Karon BS, van Buskirk CM, Jaben EA, Hoyer JD, Thomas DD (2012) Temporal sequence of major biochemical events during blood bank storage of packed red blood cells. Blood Transfus 10:453–461. doi:10.​2450/​2012.​0099-11 PubMed PubMedCentral
  Kisielewicz C, Self IA (2014) Canine and feline blood transfusions: controversies and recent advances in administration practices. Vet Anaesth Analg 41(3):233–242. doi:10.​1111/​vaa.​12135 PubMed CrossRef
  Ledent E, Berlin G (1996) Factors influencing white cell removal from red cell concentrates by filtration. Transfusion 36:714–718. doi:10.​1046/​j.​1537-2995.​1996.​36896374375.​x PubMed CrossRef
  McMichael MA, Smith SA, Galligan A et al (2010) Effect of leukoreduction on transfusion-induced inflammation in dogs. J Vet Intern Med 24(5):1131–1137. doi:10.​1111/​j.​1939-1676.​2010.​0561.​x PubMed CrossRef
  Nagura Y, Tsuno NH, Tanaka M, Matsuhashi M, Takahashi K (2013) The effect of pre-storage whole-blood leukocyte reduction on cytokines/chemokines levels in autologous CPDA-1 whole blood. Transfus Apher Sci 49(2):223–230. doi:10.​1016/​j.​transci.​2013.​01.​006 PubMed CrossRef
  Slichter SJ, Fish D, Abrams VK, Gaur L, Nelson K, Bolgiano D (2005) Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model. Blood 105(2):847–854. doi:10.​1182/​blood-2003-08-2942 PubMed CrossRef
  Smith JD, Leitman SF (2000) Filtration of RBC units: effect of storage time and temperature on filter performance. Transfusion 40:521–523. doi:10.​1046/​j.​1537-2995.​2000.​40050521.​x PubMed CrossRef
  Sollberger T, Walter R, Brand B, Contesse J, Meredith DO, Reinhart WH (2002) Influence of prestorage leucocyte depletion and storage time on rheologic properties of erythrocyte concentrates. Vox Sang 82:191–197. doi:10.​1046/​j.​1423-0410.​2002.​00167.​x PubMed CrossRef
  Wortham ST, Ortolano GA, Wenz BA (2003) Brief history of blood filtration: clot screens, microaggregate removal, and leukocyte reduction. Transfus Med Rev 17(3):216–222. doi:10.​1016/​S0887-7963(03)00023-3 PubMed CrossRef
  
• 作者单位：Marcia Kikuyo Notomi (1)
  Rafael Ruiz de Gopegui (2)
  Pierre Barnabé Escodro (1)
  
  1. Faculty of Veterinary Medicine, University Federal of Alagoas, Fazenda São Luiz, /n, Viçosa, CEP: 57700-000, Alagoas, Brazil
  2. Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Autonomy of Barcelona, 08193, Bellaterra, Barcelona, Spain
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

Leukoreduction is the removal of leukocytes from a blood component to avoid the adverse reactions resulting from the exposure of leukocytes from a donor to the recipient during transfusion. A leukoreduced blood component has been defined as achieving a concentration of less than 5 × 106 residual donor leukocytes per final blood product while maintaining 85 % of the original red blood cell count. In the present study, we evaluated the efficiency of leukocyte filtration using a BioR 01-plus blood filter (Fresenius Hemocare, Germany) on samples of whole blood in citrate-phosphate-dextrose-adenine (CPDA-1) anticoagulant from 21 dogs. The blood cell count, red blood cells (RBCs), white blood cells (WBCs) and platelets; haemoglobin concentration; packed cell volume (PCV); mean corpuscular volume (MCV); RBC distribution width (RDW); morphologic index (MI) and RBC morphology were evaluated pre-filtration, post-filtration and after storage for 28 days at 4 °C. After filtration, a significant reduction in leukocyte (98 %) and platelet (95.1 %) counts were observed, while the RBCs, haemoglobin concentration and PCV remained within the recommended levels; storage did not change these parameters. Keywords Dog Blood bank Transfusion Leukocytes Leukodepletion