Nephrotisches Syndrom im Kindesalter

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• 作者：Dr. M.R. Benz (1)
  M.J. Kemper (2)
  
  1. P盲diatrische Nephrologie ; Klinik und Poliklinik f眉r Kinder- und Jugendmedizin ; Uniklinik K枚ln ; Kerpener Str. 62 ; 50937 ; K枚ln ; Deutschland
  2. P盲diatrische Nephrologie ; Klinik f眉r Kinder- und Jugendmedizin ; Universit盲tsklinikum Hamburg-Eppendorf ; Hamburg ; Deutschland
  
• 关键词：Klassifikation ; Eintrittsalter ; Rezidiv ; Medikamentenassoziierte Effekte und Nebenwirkungen ; Glukokortikoide ; Classification ; Age of onset ; Relapse ; Drug ; related side effects and adverse reactions ; Glucocorticoids
• 刊名：Monatsschrift Kinderheilkunde
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：163
• 期：4
• 页码：310-322
• 全文大小：973 KB
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  8. Colin E, Huynh Cong E, Mollet G et al (2014) Loss-of-function mutations in WDR73 are responsible for microcephaly and steroid-resistant nephrotic syndrome: galloway-mowat-syndrome. Am J Hum Genet. http://dx.doi.org/10.1016/j.ajhg.2014.10.011
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  29. Lawrenz CE (2010) Inzidenzanalyse des nephrotischen Syndroms im Kindes- und Jugendalter in der Jahren 2005鈥?006. Inauguraldissertation, Rheinische Friedrich-Wilhelm-Universit盲t, Bonn. http://hss.ulb.uni-bonn.de/2010/2170/2170.pdf
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  37. Sinha A, Saha A, Kumar M et al (2014) Extending initial prednisolone treatment in a randomized control trial from 3 to 6 months did not significantly influence the course of illness in children with steroid-sensitive nephrotic syndrome. Kidney Int. DOI 10.1038/ki.2014.240
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  44. Klaassen I, Kemper M (2010) Das nephrotische Syndrom im Kindesalter. Kinder- und Jugendmedizin 10:203鈥?10
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  General Practice and Family Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0474

文摘

Despite being an orphan disease, idiopathic nephrotic syndrome in children is the most frequent glomerular disease in this age group. Nephrotic syndrome is characterized by severe proteinuria and hypoalbuminemia. Edema is mostly present, especially at initial presentation. Nephrotic syndrome in children is a heterogeneous disease with respect to age of onset, etiology, histology and response to the standard treatment with glucocorticoids. This diversity strongly influences the diagnostic approach and treatment. As the prognosis of steroid-sensitive nephrotic syndrome with respect to renal function is generally good, not only the efficacy but also the toxicity of different treatment regimens should be kept in mind when planning individualized treatment.