Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation
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- 作者：Su Yao ; Fangping Xu ; Yu Chen ; Yan Ge…
- 关键词：Fbw7 ; Stat3 ; DLBCL ; Activated B ; cell ; Apoptosis ; Ubiquitylation
- 刊名：Journal of Experimental & Clinical Cancer Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：36
- 期：1
- 全文大小：5308KB
- 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
- 出版者：BioMed Central
- ISSN：1756-9966
- 卷排序：36
文摘
BackgroundThe ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear.