DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer

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• 作者：L. J. Song ; Q. Liu ; X. R. Meng ; SH. L Li ; L. X. Wang ; Q. X. Fan…
• 关键词：HCC ; DLC ; 1 ; Rho A ; ROCK2 ; moesin
• 刊名：Diagnostic Pathology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：11
• 期：1
• 全文大小：1,798 KB
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• 作者单位：L. J. Song (1)
  Q. Liu (2)
  X. R. Meng (1)
  SH. L Li (3)
  L. X. Wang (1)
  Q. X. Fan (1)
  X. Y. Xuan (4)
  
  1. Department of Oncology, the first affiliated hospital of Zhengzhou University, Henan, 450000, China
  2. Department of Neurosurgery, the fifth affiliated hospital of Zhengzhou University, Henan, 450000, China
  3. Department of Pathology, the first affiliated hospital of Zhengzhou University, Henan, 450000, China
  4. Department of Microbiology and Immunology, Basic Medical School of Zhengzhou University, 100 Kexue Road, Zhengzhou, Henan, 450001, China
  
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596

文摘

Background The 5-year survival rate of patients with hepatocellular cancer (HCC) was very low because of invasion and metastasis in the early stage. Biomarkers might help predict early occurrence of invasion and metastasis. Accumulating evidence has shown that deleted in liver cancer-1 (DLC1) may be considered as a metastasis suppressor gene in numerous solid and hematological cancers. However, its prognostic role and mechanisms that regulate and coordinate these activities remain poorly understood.