Complications neurologiques centrales des traitements anticancéreux, ce que le réanimateur doit savoir

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• 作者：F. Bompaire ; O. Aupee ; D. Ricard ; D. Psimaras
• 关键词：Radiation therapy ; Chemotherapy ; Acute encephalopathy ; Epilepsy ; Posterior reversible encephalopathy ; Progressive multifocal leukoencephalopathy ; Cerebral vascular events
• 刊名：Médecine Intensive Réanimation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：75-84
• 全文大小：
• 刊物主题：Emergency Medicine; Anesthesiology; Intensive / Critical Care Medicine;
• 出版者：Lavoisier
• ISSN：1951-6959
• 卷排序：26

文摘

Cerebral radiation therapy and chemotherapies can trigger central nervous system complications. For some products and protocols, neurological toxicity is a dose-limiting parameter. Clinical characteristics including acute encephalopathy, epilepsy, posterior reversible encephalopathy, progressive multifocal leukoencephalopathy, and vascular events are well described. Numerous products are involved in these complications and most have a specific toxicity profile. As more and more complex regimens are used, including several cytotoxic drugs and innovative targeted therapies, new toxicity profiles are emerging. The determination of the drug precisely involved in the patients’ symptoms is getting more difficult. A good knowing of these complications and the implicated agents helps managing oncologic and reanimation care. Oncological prognostic has to be considered in the therapeutic discussion.