The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice
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- 作者：José Manuel Villalba ; José Alberto López-Domínguez ; Yana Chen…
- 关键词：Apoptotic signaling ; Calorie restriction ; Dietary fat ; Lifespan ; Mitochondria ; Proton leak
- 刊名：Biogerontology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：16
- 期：5
- 页码：655-670
- 全文大小：564 KB
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Cha MC, Jones PJ (2000) Energy restriction dilutes the changes related to dietary fat type in membrane phospholipid fatty acid - 作者单位：José Manuel Villalba (1)
José Alberto López-Domínguez (1)
Yana Chen (3)
Husam Khraiwesh (1)
José Antonio González-Reyes (1)
Lucía Fernández del Río (1)
Elena Gutiérrez-Casado (1)
Mercedes del Río (1)
Miguel Calvo-Rubio (1)
Julia Ariza (1)
Rafael de Cabo (4)
Guillermo López-Lluch (2)
Plácido Navas (2)
Kevork Hagopian (3)
María Isabel Burón (1)
Jon Jay Ramsey (3)
1. Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus Rabanales, Edificio Severo Ochoa, 3a planta, Campus de Excelencia Internacional Agroalimentario, ceiA3, 14014, Córdoba, Spain
3. Department of Molecular Biosciences, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive -VM3B, Davis, CA, 95616, USA
4. Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
2. Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC, and CIBERER, Instituto de Salud Carlos III, Seville, Spain - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Geriatrics and Gerontology
Developmental Biology - 出版者：Springer Netherlands
- ISSN：1573-6768
文摘
The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR) without malnutrition extends lifespan in many model organisms, which may be related to alterations in membrane phospholipids fatty acids. During the last few years our research focused on studying how altering the predominant fat source affects the outcome of CR in mice. We have established four dietary groups: one control group fed 95 % of a pre-determined ad libitum intake (in order to prevent obesity), and three CR groups fed 40 % less than ad libitum intake. Lipid source for the control and one of the CR groups was soybean oil (high in n-6 PUFA) whereas the two remaining CR groups were fed diets containing fish oil (high in n-3 PUFA), or lard (high in saturated and monounsaturated fatty acids). Dietary intervention periods ranged from 1 to 18 months. We performed a longitudinal lifespan study and a cross-sectional study set up to evaluate several mitochondrial parameters which included fatty acid composition, H+ leak, activities of electron transport chain enzymes, ROS generation, lipid peroxidation, mitochondrial ultrastructure, and mitochondrial apoptotic signaling in liver and skeletal muscle. These approaches applied to different cohorts of mice have independently indicated that lard as a fat source often maximizes the effects of 40 % CR on mice. These effects could be due to significant increases of monounsaturated fatty acids levels, in accordance with the Membrane Theory of Aging. Keywords Apoptotic signaling Calorie restriction Dietary fat Lifespan Mitochondria Proton leak