Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins
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- 作者：Nora Zidane (21) (22)
Philippe Dussart (23)
Laetitia Bremand (23)
Hugues Bedouelle (21) (22) - 关键词：Cross ; reactivity ; Dengue Virus ; Discrimination ; Flavivirus ; Human Serums ; Immunoglobulin M ; MAC ; ELISA ; ROC Curve ; Serotype ; Specificity
- 刊名：BMC Infectious Diseases
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：234KB
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79. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/302/prepub - 作者单位：Nora Zidane (21) (22)
Philippe Dussart (23)
Laetitia Bremand (23)
Hugues Bedouelle (21) (22)
21. Department of Infection and Epidemiology, Institut Pasteur, Unit of Molecular Prevention and Therapy of Human Diseases, rue du Docteur Roux, F-75015, Paris, France
22. CNRS URA3012, rue du Docteur Roux, F-75015, Paris, France
23. Institut Pasteur de la Guyane, Laboratory of Virology, National Reference Center for Arboviruses, Cayenne, French Guiana
文摘
Background Dengue fever is the most important vector-borne viral disease. Four serotypes of dengue virus, DENV1 to DENV4, coexist. Infection by one serotype elicits long-lasting immunity to that serotype but not the other three. Subsequent infection by a different serotype is a risk factor for severe dengue. Domain III (ED3) of the viral envelope protein interacts with cell receptors and contains epitopes recognized by neutralizing antibodies. We determined the serotype specificity and cross-reactivity of human IgMs directed against ED3 by using a well-characterized collection of 90 DENV-infected and 89 DENV-uninfected human serums. Methods The recognitions between the four serotypes of ED3 and the serums were assayed with an IgM antibody-capture ELISA (MAC-ELISA) and artificial homodimeric antigens. The results were analyzed with Receiving Operator Characteristic (ROC) curves. Results The DENV-infected serums contained IgMs that reacted with one or several ED3 serotypes. The discrimination by ED3 between serums infected by the homotypic DENV and uninfected serums varied with the serotype in the decreasing order DENV1-gt;?DENV2-gt;?DENV3-gt;?DENV4. The ED3 domain of DENV1 gave the highest discrimination between DENV-infected and DENV-uninfected serums, whatever the infecting serotype, and thus behaved like a universal ED3 domain for the detection of IgMs against DENV. Some ED3 serotypes discriminated between IgMs directed against the homotypic and heterotypic DENVs. The patterns of cross-reactivities and discriminations varied with the serotype. Conclusions The results should help better understand the IgM immune response and protection against DENV since ED3 is widely used as an antigen in diagnostic assays and an immunogen in vaccine candidates.