Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection
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- 作者：Rosalinda Madonna ; Christian Cadeddu ; Martino Deidda ; Donato Mele…
- 关键词：Cancer therapy ; induced cardiac injury ; Preclinical models ; Cardioprotection ; Mitochondria ; Neuregulin ; 1 ; Oxidative stress ; Statins ; Beta ; blockers ; ACE inhibitors ; Cardiac stem cells
- 刊名：Heart Failure Reviews
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：20
- 期：5
- 页码：621-631
- 全文大小：437 KB
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Christian Cadeddu (4)
Martino Deidda (4)
Donato Mele (5)
Ines Monte (6)
Giuseppina Novo (7)
Pasquale Pagliaro (8)
Alessia Pepe (9)
Paolo Spallarossa (10)
Carlo Gabriele Tocchetti (11)
Concetta Zito (12)
Giuseppe Mercuro (4)
1. Center of Excellence on Aging, Institute of Cardiology, 鈥淕. d鈥橝nnunzio鈥?University 鈥?Chieti, Chieti, Italy
2. Texas Heart Institute, Houston, TX, USA
3. Cardiology Division, Department of Internal Medicine, University of Texas Medical School, Houston, TX, USA
4. Department of Medical Sciences 鈥淢ario Aresu鈥? University of Cagliari, Cagliari, Italy
5. Cardiology Unit, University Hospital of Ferrara, Ferrara, Italy
6. Department of General Surgery and Medical-Surgery Specialties, University of Catania, Catania, Italy
7. Chair and Division of Cardiology, University of Palermo, Palermo, Italy
8. Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
9. U.O.C. Magnetic Resonance Imaging, Fondazione G. Monasterio C.N.R., Pisa, Italy
10. Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy
11. Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy
12. U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico 鈥淕. Martino鈥? University of Messina, Messina, Italy - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Cardiology - 出版者：Springer Netherlands
- ISSN：1573-7322
文摘
Although treatment for heart failure induced by cancer therapy has improved in recent years, the prevalence of cardiomyopathy due to antineoplastic therapy remains significant worldwide. In addition to traditional mediators of myocardial damage, such as reactive oxygen species, new pathways and target cells should be considered responsible for the impairment of cardiac function during anticancer treatment. Accordingly, there is a need to develop novel therapeutic strategies to protect the heart from pharmacologic injury, and improve clinical outcomes in cancer patients. The development of novel protective therapies requires testing putative therapeutic strategies in appropriate animal models of chemotherapy-induced cardiomyopathy. This Position Paper of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology aims to: (1) define the distinctive etiopatogenetic features of cardiac toxicity induced by cancer therapy in humans, which include new aspects of mitochondrial function and oxidative stress, neuregulin-1 modulation through the ErbB receptor family, angiogenesis inhibition, and cardiac stem cell depletion and/or dysfunction; (2) review the new, more promising therapeutic strategies for cardioprotection, aimed to increase the survival of patients with severe antineoplastic-induced cardiotoxicity; (3) recommend the distinctive pathological features of cardiotoxicity induced by cancer therapy in humans that should be present in animal models used to identify or to test new cardioprotective therapies.