Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice

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• 作者：Dong Xia ; Bing Liu ; Wenyu Xin ; Tongshen Liu ; Junyan Sun…
• 关键词：C ; phycocyanin ; Subacute ethanol liver injury ; Improves immunity ; Protective effect
• 刊名：Journal of Applied Phycology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：28
• 期：2
• 页码：765-772
• 全文大小：799 KB
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• 作者单位：Dong Xia (1)
  Bing Liu (2)
  Wenyu Xin (3)
  Tongshen Liu (3)
  Junyan Sun (2)
  Nana Liu (2)
  Song Qin (2)
  Zhenning Du (1)
  
  1. School of Pharmacy, Yantai University, Yantai, 264005, China
  2. Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China
  3. School of Basic Medicine, Binzhou Medical University, Yantai, 264003, China
  
• 刊物主题：Plant Sciences; Freshwater & Marine Ecology; Plant Physiology; Ecology;
• 出版者：Springer Netherlands
• ISSN：1573-5176

文摘

Excessive and long-term alcohol consumption leads to liver disease and low immunity. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Arthrospira (Spirulina) platensis, exerts protective effects against chemical-induced organ damage and improves immunity. In this study, we investigated whether C-PC could protect against ethanol-induced subacute liver injury and improve immunity. KM mice with ethanol-induced liver injury were established, and animals were divided into three groups that were treated with high, medium, and low doses of C-PC. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), total bilirubin (TBIL), liver homogenate malondialdehyde (MDA), and superoxide dismutase (SOD) levels were measured. In addition, the number of thymus T cell subsets was assessed, and liver sections were examined pathologically. C-PC exhibited obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL, and MDA levels and increased SOD content significantly in the liver. C-PC also increased serum CD3+ and CD4+ cell activation and T cell proliferation significantly compared with the model group. The structure of the hepatic lobules was clear, the liver sinus returned to normal, and the liver cell cords were arranged in neat rows. Therefore, C-PC could protect against ethanol-induced subacute liver injury significantly.