Interaction of tumor necrosis alpha – G308A and epidermalgrowth factor gene polymorphisms in early–onset schizophrenia

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• 作者：O. Kampman ; S. Anttila ; A. Illi ; K. M. Mattila ; R. Rontu ; E. Leinonen and T. Lehtim?ki
• 关键词：biological psychiatry ; psychopharmacology ; pharmacogenetics ; antipsychotic agents ; cytokines
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2005
• 出版时间：August 2005
• 年：2005
• 卷：255
• 期：4
• 页码：279-283
• 全文大小：275 KB

文摘

The study population comprised 94Finnish patients with DSM-IV diagnosis of schizophrenia.The patients were placed into two subgroups accordingto medication response to conventional neuroleptics.The aim of the study was to examine thefrequency of tumor necrosis factor –308 (G > A) polymorphismin these patients and their 98 control subjectswho were age– and gender–matched blood donors. Associationsbetween TNFα –308 polymorphism alone andbetween the interaction of TNFα and epidermal growthfactor gene polymorphisms, and medication responseand age at onset of schizophrenia were also studied. Thefrequencies of TNFα A–allele were 11.7 % in patients and12.8 % in controls. The difference was not significant(p = 0.75). TNFα –308 polymorphism was not associatedwith medication response. However, patients with EGFAA and TNFα AG/AA genotype had a lower age at onsetof schizophrenia compared with the rest of the patientsnot having this combination (20.0 years, 3.3 vs. 30.2years, 10.1 mean + SD; p TNFα polymorphismis not associated with the incidence of schizophrenia.On the other hand, the role of cytokines inschizophrenia may involve genetic interactions predisposingearly onset of illness.