Factors associated with lateral pelvic recurrence after curative resection following neoadjuvant chemoradiotherapy in rectal cancer patients

详细信息    查看全文

• 作者：Tae Gyu Kim (1)
  Won Park (2)
  Doo Ho Choi (2)
  Hee Chul Park (2)
  Seok-Hyung Kim (3)
  Yong Beom Cho (4)
  Seong Hyeon Yun (4)
  Hee Cheol Kim (4)
  Woo Yong Lee (4)
  Jeeyun Lee (5)
  Joon Oh Park (5)
  Young Suk Park (5)
  Ho Yeong Lim (5)
  Won Ki Kang (5)
  Ho-Kyung Chun (6)
  
• 关键词：Rectal cancer ; Neoadjuvant chemoradiotherapy ; Lateral lymph node ; Lateral pelvic recurrence
• 刊名：International Journal of Colorectal Disease
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：29
• 期：2
• 页码：193-200
• 全文大小：313 KB
• 作者单位：Tae Gyu Kim (1)
  Won Park (2)
  Doo Ho Choi (2)
  Hee Chul Park (2)
  Seok-Hyung Kim (3)
  Yong Beom Cho (4)
  Seong Hyeon Yun (4)
  Hee Cheol Kim (4)
  Woo Yong Lee (4)
  Jeeyun Lee (5)
  Joon Oh Park (5)
  Young Suk Park (5)
  Ho Yeong Lim (5)
  Won Ki Kang (5)
  Ho-Kyung Chun (6)
  
  1. Department of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
  2. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, 137-710, Seoul, Republic of Korea
  3. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  4. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  5. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  6. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  
• ISSN：1432-1262

文摘

Purpose This study aims to determine the risk factors for lateral pelvic recurrence (LPR) in rectal cancer patients treated with neoadjuvant chemoradiotherapy (CRT) and curative surgery. Methods Four hundred forty-three patients treated with neoadjuvant CRT and curative surgery from October 1999 through June 2009 were analyzed. All patients underwent total mesorectal resection without lateral pelvic lymph node (LPLN) dissection. Recurrence patterns and lateral pelvic recurrence-free survival (LPFS) were evaluated relative to clinicopathologic parameters including pelvic LN status. Results Median follow-up was 52?months, with locoregional recurrence in 53 patients (11.9?%). Of the 53 patients, 28 (52.8?%) developed LPR, of which eight had both central and lateral PR. Multivariate analysis showed a significant relationship between LPFS and the number of lateral pelvic LN (p--.010) as well as the ratio of the number of positive LN/number of dissected LN (p--.038). The relationship between LPFS and LPLN size had a marginal trend (p--.085). Logistic regression analysis showed positive relationships between LPR probability and the number of LPLN (odds ratio [OR] 1.507; 95?% confidence interval [CI] 1.177-.929; p--.001) as well as LPLN size (OR 1.124; CI 1.029-.227, p--.009). Conclusions LPLN?≥- and a ratio of the number of positive LN/number of dissected LN-gt;-.3 were prognostic of poor LPFS. The prediction curve of LPR according to the number and size of LPLN could be useful for determining the benefit of additional lateral pelvic treatment.