Duration of Hormone Replacement Therapy, Breast Tumour Size and Grade in a Screening Programme

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• 作者：Dorota M Gertig ; Bircan Erbas ; Ashley Fletcher ; Alison Amos and Anne M Kavanagh
• 关键词：breast cancer ; epidemiology ; histology ; hormone replacement therapy ; screening
• 刊名：Breast Cancer Research and Treatment
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：80
• 期：3
• 页码：267-273
• 全文大小：75 KB

文摘

One of the primary adverse effects of long-term use of hormone replacement therapy (HRT) is a modest increase in the risk of breast cancer. Breast tumours that develop in women using HRT have been shown to have prognostically favourable histological features but it is unclear if this is the case for both short- and long-term use.Methods. We evaluated the association between HRT use with tumour size and histologic grade in a cohort of women aged over 55 years (n = 2200) diagnosed with invasive breast cancer at subsequent screen in BreastScreen Victoria (BSV), Australia between 1993 and 2000. BSV biennially screens women aged over 40 years with the target age group 50–69 years. Multiple linear regression was used to examine predictors of log-transformed tumour size and multinomial logistic regression was used to evaluate associations of HRT with tumour grade.