Cytological Screening for Barrett’s Esophagus Using a Prototype Flexible Mesh Catheter

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• 作者：Rader ; Anne E. ; Faigel ; Douglas O. ; Ditomasso ; John ; Magaret ; Nathan ; Burm ; Michael ; Fennerty ; M. Brian
• 关键词：Barrett's esophagus ; catheter ; gastroesophageal reflux disease ; screening
• 刊名：Digestive Diseases and Sciences
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：46
• 期：12
• 页码：2681-2686
• 全文大小：742 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett’s esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE using a prototype flexible mesh catheter. Patients with known BE undergoing indicated surveillance endoscopy were enrolled in the study. Cytology specimens were obtained using a prototype flexible catheter and were evaluated for the presence of glandular cells, goblet cells, squamous cells, inflammation, and dysplasia. Eleven patients with BE were enrolled in the study. None of the patients experienced complications. Specimens from eight patients (73%) were adequate for evaluation and seven of these patients (87.5%) had goblet cells diagnostic for BE. In conclusion, flexible mesh catheters potentially offer a sensitive, inexpensive, and minimally invasive approach to evaluating patients with GERD and BE.