Substituted 2-aminonicotinamides in the synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones, 2,3-dihydropyrido- [2,3-d]pyrimidin-4(1H)-ones, and 11b,12-dihydropyrido- [2',3':4,5]pyrimido[2,1-a]isoindole-5,7-diones

详细信息    查看全文

• 作者：E. A. Sidorova (1)
  E. S. Kostenko (1)
  I. S. Arustamova (1)
  E. A. Kaigorodova (1) e_kaigorodova@mail.ru
  L. D. Konyushkin (2) leonidk@chemical-block.com
• 关键词：2 ; aminonicotinamides – ; 2 ; 3 ; dihydropyrido[2 ; 3 ; d]pyrimidin ; 4(1H) ; ones – ; pyrido[2 ; 3 ; d]pyrimi ; din ; 4(1H) ; ones – ; 5 ; 7 ; 11b ; 12 ; tetrahydropyrido[2' ; 3' ; 4 ; 5] ; pyrimido[2 ; 1 ; a]isoindole ; 5 ; 7 ; diones – ; heterocyclization
• 刊名：Chemistry of Heterocyclic Compounds
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：47
• 期：3
• 页码：294-301
• 全文大小：343.9 KB
• 参考文献：1. W. P. Purcell, R. D. Gilliom, and H. A. Parish, US Patent 4361700; Chem. Abstr., 98, 89387 (1983).
  2. M. Mohsen, J. Serb. Chem. Soc., 56, 383 (1991); Ref. Zh. Khim., 4zh291 (1992).
  3. A. Monge, V. Martinez-Merino, M. A. Simon, and C. Sanmartin, J. Heterocycl. Chem., 29, 1545 (1992).
  4. H. A. Parish, R. D. Gilliom, W. P. Purcell, R. K. Browne, R. F. Spirk, and H. D. White, J. Med. Chem., 25, 98 (1982).
  5. V. D. Strelkov, in: Proceedings of the International Technological Conference "Biological Plant Protection, a Basis for Stabilizing Agroecosystems" [in Russian], Krasnodar (2004), p. 393.
  6. V. P. Litvinov, L. A. Rodinovskaya, Yu. A. Sharanin, and A. M. Shestopalov, Sulfur Rep., 13, 1 (1992).
  7. N. I. Shram and M. E. Konshin, Khim. Geterotsikl. Soedin., 114 (1985). [Chem. Heterocycl. Comp., 21, 93 (1985)].
  8. L. M. Demina and M. E. Konshin, Khim. Geterotsikl. Soedin., 1234 (1992). [Chem. Heterocycl. Comp., 28, 1046 (1992)].
  9. I. S. Arustamova and V. T. Piven', Khim. Geterotsikl. Soedin., 61 (1999). [Chem. Heterocycl. Comp., 35, 58 (1999)].
  10. R. Kwork, J. Heterocycl. Chem., 15, 877 (1978).
• 作者单位：1. Kuban State Agrarian University, 13 Kalinina St., Krasnodar, 350044 Russia2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, Moscow, 119991 Russia
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Organic Chemistry
  Pharmacy
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-8353

文摘

The reactions of 2-aminonicotinamides with triethyl orthoformate, carboxylic acids chlorides, aldehydes, and 2-formylbenzoic acid were studied. As a result pyrido[2,3-d]pyrimidin-4(1H)-ones, 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones, and 5,7,11b,12-tetrahydropyrido[2',3':4,5]pyrimido- [2,1-a]isoindole-5,7-diones were obtained.