Synthesis of 4-aminopyrazolo[3,4-d]pyrimidine derivatives from 5-acetyl-6-amino-4-methylsulfanyl- or 5-acetyl-6-amino-4-methylsulfonylpyrimidines

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• 作者：A. V. Komkov (1)
  V. A. Voronkova (1)
  A. S. Shashkov (1)
  V. A. Dorokhov (1)
  
• 关键词：5 ; acetyl ; 6 ; amino ; 4 ; methylsulfanylpyrimidines ; oxidation ; m ; chloroperbenzoic acid ; 5 ; acetyl ; 6 ; amino ; 4 ; methylsulfonylpyrimidines ; 4 ; amino ; 1H ; pyrazolo[3 ; 4 ; d]pyrimid ; ines ; 4 ; amino ; 2 ; phenyl ; 2H ; pyrazolo[3 ; 4 ; d]pyrimidines ; hydrazines
• 刊名：Russian Chemical Bulletin
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：61
• 期：2
• 页码：332-342
• 全文大小：362KB
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• 作者单位：A. V. Komkov (1)
  V. A. Voronkova (1)
  A. S. Shashkov (1)
  V. A. Dorokhov (1)
  
  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
  
• ISSN：1573-9171

文摘

Diacetyl ketene N,S-acetal was used for the synthesis of 5-acetyl-6-amino-4-methylsulfanylpyrimidines substituted at the exocyclic nitrogen atom, which were further oxidized with m-chloroperbenzoic acid to the corresponding methylsulfonylpyrimidines. Reactions of hydrazines with these pyrimidines containing vicinal Ac and MeS (or MeSO2) groups were used for the preparation of new 4-aminopyrazolo[3,4-d]pyrimidine derivatives.