HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study
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- 作者：Dovilė Ražanskaitė-Virbickienė ; Evalda Danytė ; Rimantas Žalinkevičius
- 关键词：Type 1 diabetes mellitus ; Albuminuria ; AER ; HLA ; DR3 ; DR4
- 刊名：BMC Nephrology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：439 KB
- 刊物主题：Nephrology; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2369
文摘
Background Increased urinary albumin excretion rate is the earliest clinical manifestation of diabetic nephropathy. The development of microalbuminuria in patients with type 1 diabetes mellitus (T1D) usually begins 5 to 15 years after the onset of diabetes. The rate of progression of diabetic nephropathy varies considerably among patients and not always can be explained solely by glycaemic control. The evidence suggests that genetic susceptibility may play a role in the development of diabetes microvascular complications, besides the presence of such risk factors as hyperglycaemia, hypertension, dyslipidaemia and smoking. The aim of the study was to evaluate a link between known genetic risk factors for type 1 diabetes mellitus (HLA-DR3/DR4) and microalbuminuria among patients with the same durations of diabetes.