A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L
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- 作者：S. Jongen ; A. Vermeeren ; N. N. J. J. M. van der Sluiszen…
- 关键词：Alcohol ; On ; the ; road driving ; Standard deviation of lateral position ; Clinical relevance
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：234
- 期：5
- 页码：837-844
- 全文大小：1092KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
IntroductionThe on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of lateral position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.