Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma

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• 作者：Minhui Xu (5) (6)
  Feng Xie (7)
  Guangyang Qian (6)
  Yingying Jing (6)
  Shanshan Zhang (6)
  Lu Gao (6)
  Tao Zheng (7)
  Mengchao Wu (6) (7)
  Jiamei Yang (7)
  Lixin Wei (6)
  
• 关键词：Ductular reaction (DR) ; Hepatic progenitor cells (HPCs) ; Necroinflammation ; Fibrosis ; Hepatocellular carcinoma (HCC) ; Prognosis
• 刊名：BMC Cancer
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：498 KB
• 作者单位：Minhui Xu (5) (6)
  Feng Xie (7)
  Guangyang Qian (6)
  Yingying Jing (6)
  Shanshan Zhang (6)
  Lu Gao (6)
  Tao Zheng (7)
  Mengchao Wu (6) (7)
  Jiamei Yang (7)
  Lixin Wei (6)
  
  5. The Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
  6. Tumor Immunology & Gene Therapy Center, Eastern Hepatobiliary Hospital, The Second Military Medical University, Changhai Road, Shanghai, 200438, China
  7. Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
  
• ISSN：1471-2407

文摘

Background The role of ductular reaction (DR) in hepatocellular carcinoma (HCC) remains to be elucidated. Methods In this study, we tried to uncover possible effect by correlating peritumoral DR in a necroinflammatory microenvironment with postoperative prognosis in HCC. The expression of peritumoral DR/CK19 by immunohistochemistry, necroinflammation and fibrosis were assessed from 106 patients receiving curative resection for HCC. Prognostic values for these and other clinicopathologic factors were evaluated. Results Peritumoral DR significantly correlated with necroinflammation (r--.563, p--.4E-10), fibrosis (r--.435, p--.1E-06), AFP level (p--.010), HBsAg (p--.9E-4), BCLC stage (p--.003), TNM stage (p--.002), multiple nodules (p--.004), absence of tumor capsule (p--.027), severe microscopic vascular invasion (p--.031) and early recurrence (p--.010). Increased DR was significantly associated with decreased RFS/OS (p--.8E-04 and p--.6E-05, respectively) in univariate analysis and were identified as an independent prognostic factor (HR--.380, 95% CI--.250-4.534, p--.008 for RFS; HR--.294, 95% CI--.255-8.177, p--.3E-6 for OS) in multivariate analysis. Conclusions These results suggested that peritumoral DR in a necroinflammatory microenvironment was a poor prognostic factor for HCC after resection.