Effect of Endoscopic Gastroplication on the Genome-Wide Transcriptome in the Upper Gastrointestinal Tract
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- 作者：Nikkie van der Wielen ; Givan Paulus ; Mark van Avesaat ; Ad Masclee…
- 关键词：Gastroplication ; Transcriptome ; Gene expression ; Gastric tissue ; Duodenum ; HbA1c ; Adiponectin ; Immunity ; Inflammation
- 刊名：Obesity Surgery
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：27
- 期：3
- 页码：740-748
- 全文大小：1641KB
- 刊物主题：Surgery;
- 出版者：Springer US
- ISSN：1708-0428
- 卷排序：27
文摘
BackgroundBariatric surgery is an effective intervention strategy in obesity, resulting in sustained weight loss and a reduction of comorbidities. Gastroplication, using the articulating circular endoscopic stapler, was recently introduced as a transoral bariatric technique. This procedure reduces gastric volume and induced 34.9 % of excess weight loss in the first year (Paulus et al. Gastrointest Endosc. 81(2):312–20, 3). The aim of the present study was to gain insight in the long-term effects and underlying mechanisms of gastroplication by investigating differences in the genome-wide gastric and duodenal transcriptome before and 1 year after intervention.